Evidence map›Paper›PMID 29165333›Full record

ArticleViruses2017

Pressure for Pattern-Specific Intertypic Recombination between Sabin Polioviruses: Evolutionary Implications.

Ekaterina Korotkova, Majid Laassri, Tatiana Zagorodnyaya, Svetlana Petrovskaya, Elvira Rodionova, Elena Cherkasova, Anatoly Gmyl, Olga E Ivanova, Tatyana P Eremeeva, Galina Y Lipskaya and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.5field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 24 citations in OpenAlex.

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  14. Emergency Services of Viral RNAs: Repair and Remodeling.Microbiology and molecular biology reviews : MMBR · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Ekaterina KorotkovaAN Belozersky Institute of Physical-Chemical Biology, MV Lomonosov Moscow State University, Moscow 119899, Russia. kel@sumail.ru.
Majid LaassriUS Food and Drug Administration, Silver Spring, MD 20993, USA. majid.laassri@fda.hhs.gov.
Tatiana ZagorodnyayaUS Food and Drug Administration, Silver Spring, MD 20993, USA. tatiana.zagorodnyaya@fda.hhs.gov.
Svetlana PetrovskayaUS Food and Drug Administration, Silver Spring, MD 20993, USA. svetlana.petrovskaya@fda.hhs.gov.
Elvira RodionovaUS Food and Drug Administration, Silver Spring, MD 20993, USA. rodionova.elvira@gmail.com.
Elena CherkasovaNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20895, USA. cherkasovae@nhlbi.nih.gov.
Anatoly GmylInstitute of Poliomyelitis and Viral Encephalitides of MP Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences, Moscow 108819, Russia. apgmyl@mail.ru.
Olga E IvanovaInstitute of Poliomyelitis and Viral Encephalitides of MP Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences, Moscow 108819, Russia. ivanova_oe@chumakovs.su.
Tatyana P EremeevaInstitute of Poliomyelitis and Viral Encephalitides of MP Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products of Russian Academy of Sciences, Moscow 108819, Russia. poliom_ldms@mail.ru.
Galina Y LipskayaAN Belozersky Institute of Physical-Chemical Biology, MV Lomonosov Moscow State University, Moscow 119899, Russia. galina.lipskaya@gmail.com.
Vadim I AgolAN Belozersky Institute of Physical-Chemical Biology, MV Lomonosov Moscow State University, Moscow 119899, Russia. agol@belozersky.msu.ru.ORCID 0000-0001-9743-8145
Konstantin ChumakovUS Food and Drug Administration, Silver Spring, MD 20993, USA. konstantin.chumakov@fda.hhs.gov.
Russian Academy of Sciences · RUUnited States Food and Drug Administration · USLomonosov Moscow State University · RUNational Institutes of Health · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Complete genomic sequences of a non-redundant set of 70 recombinants between three serotypes of attenuated Sabin polioviruses as well as location (based on partial sequencing) of crossover sites of 28 additional recombinants were determined and compared with the previously published data. It is demonstrated that the genomes of Sabin viruses contain distinct strain-specific segments that are eliminated by recombination. The presumed low fitness of these segments could be linked to mutations acquired upon derivation of the vaccine strains and/or may have been present in wild-type parents of Sabin viruses. These "weak" segments contribute to the propensity of these viruses to recombine with each other and with other enteroviruses as well as determine the choice of crossover sites. The knowledge of location of such segments opens additional possibilities for the design of more genetically stable and/or more attenuated variants, i.e., candidates for new oral polio vaccines. The results also suggest that the genome of wild polioviruses, and, by generalization, of other RNA viruses, may harbor hidden low-fitness segments that can be readily eliminated only by recombination.

Indexed as

Evolution, MolecularGenome, ViralRecombination, GeneticDrug-Related Side Effects and Adverse ReactionsEnterovirus InfectionsHumansMutationPoliomyelitisPoliovirusPoliovirus Vaccine, OralVirulencePoliovirus Vaccine, Oralattenuationreversionvaccine-derived poliovirusesvaccine-induced adverse reactionsvirulence

Identifiers

PMID29165333
PMCPMC5707560
OpenAlexW2769154666

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.