ArticleeLife2017
T2N as a new tool for robust electrophysiological modeling demonstrated for mature and adult-born dentate granule cells.
Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
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- One model to rule them all: Unification of voltage-gated potassium channel models via deep non-linear mixed effects modelling.PLoS computational biology · 2026Article
- The Brain's Best Kept Secret Is Its Degenerate Structure.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
- Ultra-high frequency repetitive TMS at subthreshold intensity induces suprathreshold motor response via temporal summation.Journal of neural engineering · 2024Article
- Subcellular pathways through VGluT3-expressing mouse amacrine cells provide locally tuned object-motion-selective signals in the retina.Nature communications · 2024Article
- A biologically inspired repair mechanism for neuronal reconstructions with a focus on human dendrites.PLoS computational biology · 2024Article
- Robust and consistent measures of pattern separation based on information theory and demonstrated in the dentate gyrus.PLoS computational biology · 2024Article
- Deficits in neuronal architecture but not over-inhibition are main determinants of reduced neuronal network activity in a mouse model of overexpression of Dyrk1A.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- The Amyloid Precursor Protein Regulates Synaptic Transmission at Medial Perforant Path Synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Biological complexity facilitates tuning of the neuronal parameter space.PLoS computational biology · 2023Article
- Structural plasticity of the axon initial segment in rat hippocampal granule cells following high frequency stimulation and LTP induction.Frontiers in neuroanatomy · 2023Article
- Heterogeneous off-target impact of ion-channel deletion on intrinsic properties of hippocampal model neurons that self-regulate calcium.Frontiers in cellular neuroscience · 2023Article
- Multi-modal characterization and simulation of human epileptic circuitry.Cell reports · 2022Article
- Pareto optimality, economy-effectiveness trade-offs and ion channel degeneracy: improving population modelling for single neurons.Open biology · 2022Review
- Dominant role of adult neurogenesis-induced structural heterogeneities in driving plasticity heterogeneity in dentate gyrus granule cells.Hippocampus · 2022Article
- Active Dendrites and Local Field Potentials: Biophysical Mechanisms and Computational Explorations.Neuroscience · 2022Review
- Ion-channel degeneracy: Multiple ion channels heterogeneously regulate intrinsic physiology of rat hippocampal granule cells.Physiological reports · 2021Article
- A new reduced-morphology model for CA1 pyramidal cells and its validation and comparison with other models using HippoUnit.Scientific reports · 2021Article
- Ion-channel regulation of response decorrelation in a heterogeneous multi-scale model of the dentate gyrus.Current research in neurobiology · 2021Article
- Robust emergence of sharply tuned place-cell responses in hippocampal neurons with structural and biophysical heterogeneities.Brain structure & function · 2020Article
Corrections and comments
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5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Compartmental models are the theoretical tool of choice for understanding single neuron computations. However, many models are incomplete, built ad hoc and require tuning for each novel condition rendering them of limited usability. Here, we present T2N, a powerful interface to control NEURON with Matlab and TREES toolbox, which supports generating models stable over a broad range of reconstructed and synthetic morphologies. We illustrate this for a novel, highly detailed active model of dentate granule cells (GCs) replicating a wide palette of experiments from various labs. By implementing known differences in ion channel composition and morphology, our model reproduces data from mouse or rat, mature or adult-born GCs as well as pharmacological interventions and epileptic conditions. This work sets a new benchmark for detailed compartmental modeling. T2N is suitable for creating robust models useful for large-scale networks that could lead to novel predictions. We discuss possible T2N application in degeneracy studies.
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