ArticleeLife2017
Computational modeling of spinal circuits controlling limb coordination and gaits in quadrupeds.
Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.
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Who cites it
67 citing papers in PubMed.
- Unlocking fast robotic locomotor propulsion through dynamic spine-leg synergy.Science advances · 2026Article
- Spatial and network principles behind neural generation of locomotion.Nature communications · 2026Article
- Unified comparison of spinal locomotion control architectures in neuromechanical simulations.bioRxiv : the preprint server for biology · 2026Article
- Speed-Dependent Turning Strategies in Quadrupedal Locomotion: Insights from Computational Modeling.bioRxiv : the preprint server for biology · 2026Article
- Article
- Recovery in gait and posture: a network-based approach to the assessment of rehabilitation effectiveness after spinal cord injury.Frontiers in network physiology · 2026Article
- Speed-dependent turning strategies in quadrupedal locomotion: insights from computational modeling.Frontiers in bioengineering and biotechnology · 2026Article
- Biologically-constrained spiking neural network for neuromodulation in locomotor recovery after spinal cord injury.PLoS computational biology · 2026Article
- Mechanisms of adaptive interlimb coordination to sudden ground loss: a neuromusculoskeletal modeling study.bioRxiv : the preprint server for biology · 2025Article
- Spinal interneuron population dynamics underlying flexible pattern generation.Nature communications · 2025Article
- Precise limb-speed afference reveals rhythmogenic drive modality and declines with age.Research square · 2025Article
- Article
- Balancing central control and sensory feedback produces adaptable and robust locomotor patterns in a spiking, neuromechanical model of the salamander spinal cord.PLoS computational biology · 2025Article
- Role of forelimb morphology in muscle sensorimotor functions during locomotion in the cat.The Journal of physiology · 2025Article
- Operation of spinal sensorimotor circuits controlling phase durations during tied-belt and split-belt locomotion after a lateral thoracic hemisection.bioRxiv : the preprint server for biology · 2024Article
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- Article
- Sensory feedback and central neuronal interactions in mouse locomotion.Royal Society open science · 2024Article
- ROLE OF FORELIMB MORPHOLOGY IN MUSCLE SENSORIMOTOR FUNCTIONS DURING LOCOMOTION IN THE CAT.bioRxiv : the preprint server for biology · 2024Article
- Forelimb movements contribute to hindlimb cutaneous reflexes during locomotion in cats.Journal of neurophysiology · 2024Article
7 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Interactions between cervical and lumbar spinal circuits are mediated by long propriospinal neurons (LPNs). Ablation of descending LPNs in mice disturbs left-right coordination at high speeds without affecting fore-hind alternation. We developed a computational model of spinal circuits consisting of four rhythm generators coupled by commissural interneurons (CINs), providing left-right interactions, and LPNs, mediating homolateral and diagonal interactions. The proposed CIN and diagonal LPN connections contribute to speed-dependent gait transition from walk, to trot, and then to gallop and bound; the homolateral LPN connections ensure fore-hind alternation in all gaits. The model reproduces speed-dependent gait expression in intact and genetically transformed mice and the disruption of hindlimb coordination following ablation of descending LPNs. Inputs to CINs and LPNs can affect interlimb coordination and change gait independent of speed. We suggest that these interneurons represent the main targets for supraspinal and sensory afferent signals adjusting gait.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.