Evidence map›Paper›PMID 29165225›Full record

ArticleThe American journal of tropical medicine and hygiene2018

Prevalence of Asymptomatic Parasitemia and Gametocytemia in HIV-Infected Children on Differing Antiretroviral Therapy.

Charlotte V Hobbs, Erin E Gabriel, Portia Kamthunzi, Gerald Tegha, Jean Tauzie, Yonghua Li, Tiina Ilmet, Elena Artimovich, Jillian Neal, Ted Hall and 9 more

Open access · bronzeAbstract read
In one paragraph

Article in The American journal of tropical medicine and hygiene, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. HIV-1 Infection Is Associated With Increased Prevalence and Abundance ofFrontiers in cellular and infection microbiology · 2020
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 10 institutions in 2 countries.

Charlotte V HobbsLaboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland.
Erin E GabrielBiostatistics Research Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland.
Portia KamthunziKamuzu Central Hospital, University of North Carolina at Chapel Hill Lilongwe Project, Lilongwe, Malawi.
Gerald TeghaKamuzu Central Hospital, University of North Carolina at Chapel Hill Lilongwe Project, Lilongwe, Malawi.
Jean TauzieKamuzu Central Hospital, University of North Carolina at Chapel Hill Lilongwe Project, Lilongwe, Malawi.
Yonghua LiDepartment of Pediatrics, Division of Infectious Disease and Immunology, New York University School of Medicine, New York, New York.
Tiina IlmetCornell Clinical Trials Unit, Weill Cornell Medicine, New York, New York.
Elena ArtimovichUniversity of Maryland, Division of Malaria Research, Institute for Global Health, University of Maryland School of Medicine, Baltimore, Maryland.
Jillian NealLaboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland.
Ted HallHYDAS World Health, Inc., Hummelstown, Pennsylvania.
Sunil ParikhYale Schools of Public Health and Medicine, New Haven, Connecticut.
Brian KirmseDepartment of Pediatrics, Division of Medical Genetics, University of Mississippi Medical Center, Batson Children's Hospital, Jackson, Mississippi.
Patrick Jean-PhilippeHJF-DAIDS, Division of the Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc., Contractor to NIAID, NIH, DHHS, Bethesda, Maryland.
Jingyang ChenBen Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, University of Washington, and Fred Hutchinson Cancer Research Center, Seattle, Washington.
William R PrescottHYDAS World Health, Inc., Hummelstown, Pennsylvania.
Paul PalumboDivision of Infectious Diseases and International Health, Geisel School of Medicine at Dartmouth, Lebanon, New Hampshire.
Patrick E DuffyLaboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland.
William BorkowskyDepartment of Pediatrics, Division of Infectious Disease and Immunology, New York University School of Medicine, New York, New York.
For The P S Study Team
New York University · USKamuzu Central Hospital · MWNational Institute of Allergy and Infectious Diseases · USUniversity of North Carolina at Chapel Hill · USDartmouth College · USFred Hutch Cancer Center · USHenry M. Jackson Foundation · USNational Institutes of Health · USUniversity of Maryland, Baltimore · USUniversity of Mississippi Medical Center · US

Funding

LOC-IMPAACT Leadership GroupPharmacokinetics and Safety of Remdesivir for Treatment of COVID-19 in Pregnant Women in the USUM1AI068632 · NIAID · SOCIAL AND SCIENTIFIC SYSTEMS, INC. · PI Sharon A Nachman · 2011 to 2026
$278.1M
Statistical and Data Management Center-Pediatric,Adolescent, and Maternal CTGUM1AI068616 · NIAID · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Sean Scott Brummel, Marlene Ann Cooper · 2011 to 2026
$155.6M
University of North Carolina Global HIV Prevention and Treatment Clinical Trials Unit 2024 SupplementUM1AI069423 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Joseph J Eron, MINA CHRISTINE HOSSEINIPOUR · 2012 to 2026
$71.8M
LC - IMPAACT Leadership GroupUM1AI106716 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Grace M Aldrovandi · 2014 to 2026
$47.2M
Statistical and Data Management Center-Pediatric,Adolescent, and Maternal CTGU01AI068616 · NIAID · HARVARD SCHOOL OF PUBLIC HEALTH · PI SHAPIRO, DAVID ERIC · 2006 to 2010
$38.6M
Malaria Pathogenesis in young children and vaccine discoveryZIAAI001134 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI DUFFY, PATRICK · 2010 to 2025
$11.3M
NIAID NIH HHS U01 AI068616NIAID NIH HHS UM1 AI068616NIAID NIH HHS UM1 AI068632NIAID NIH HHS UM1 AI069423NIAID NIH HHS UM1 AI106716
6 · The paper itself

Abstract

Laboratory data and prior pediatric reports indicate that HIV protease inhibitor (PI)-based antiretroviral therapy (ARV) kills gametocytes and reduces rates of gametocytemia, but not asymptomatic parasitemia, in a high malaria-transmission area. To determine whether ARV regimen impacts these rates in areas with less-intense malaria transmission, we compared asymptomatic parasitemia and gametocytemia rates in HIV-infected children by ARV regimen in Lilongwe, Malawi, an area of low-to-moderate transmission intensity. HIV PI lopinavir-ritonavir (LPV-rtv) ARV- or non-nucleoside reverse transcriptase inhibitor nevirapine ARV-treated children did not differ in the rates of polymerase chain reaction-detected asymptomatic parasitemia (relative risk [RR] 0.43 95% confidence interval [CI] [0.16, 1.18],

Indexed as

Africa South of the SaharaAnti-HIV AgentsAsymptomatic InfectionsChild, PreschoolCoinfectionFemaleHIV InfectionsHumansInfantMalaria, FalciparumMaleMicrosatellite RepeatsParasitemiaPlasmodium falciparumPrevalenceAnti-HIV Agents

Identifiers

PMID29165225
PMCPMC5928720
OpenAlexW2770711435

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.