ArticleEnvironmental health and preventive medicine2017
Sasa veitchii extracts suppress acetaminophen-induced hepatotoxicity in mice.
Article in Environmental health and preventive medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 22 citations in OpenAlex.
- Effects of Sasa veitchii extract on intestinal epithelial cells and gut microbiota.Journal of natural medicines · 2026Article
- Hepatoprotective effects ofFood science & nutrition · 2024Article
- Protective effect ofNagoya journal of medical science · 2024Article
- Copper-induced diurnal hepatic toxicity is associated with Cry2 and Per1 in mice.Environmental health and preventive medicine · 2023Article
- Novel strategies for the treatment of acetaminophen hepatotoxicity.Expert opinion on drug metabolism & toxicology · 2020Review
- Article
- Inhibitory activity of black mulberry (Morus nigra) extract against testicular, liver and kidney toxicity induced by paracetamol in mice.Molecular biology reports · 2020Article
- In vitro Antioxidant and in vivo Hepatoprotective Activities of Root Bark Extract and Solvent Fractions ofJournal of experimental pharmacology · 2020Article
- 4-hydroxy-2(3H)-benzoxazolone alleviates acetaminophen-induced hepatic injury by inhibiting NF-κB and activating Nrf2/HO-1 signaling pathways.American journal of translational research · 2020Article
- Herbal Therapy for the Treatment of Acetaminophen-Associated Liver Injury: Recent Advances and Future Perspectives.Frontiers in pharmacology · 2020Review
- Article
- Sasa veitchii extract protects against carbon tetrachloride-induced hepatic fibrosis in mice.Environmental health and preventive medicine · 2018Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim of this study was to investigate the therapeutic effects of a Sasa veitchii leaf extract (SE) on acetaminophen (APAP)-induced hepatotoxicity.
methodsSeven-week-old male ddY mice were orally administered SE or saline (0.2 mL) once a day for a week. Twenty-four hours after the last pretreatment, the mice were intraperitoneally injected with 550 mg/kg APAP or saline under fasting conditions. The mice from each group were euthanized and bled for plasma analysis 2, 6, 24, and 72 h after the injection.
resultsWe found that pretreatment with SE significantly decreased hepatic injury markers (i.e., alanine aminotransferase and aspartate aminotransferase), oxidative stress (malondialdehyde and glutathione level), inflammatory cytokines, histological damage, c-jun N-terminal kinase activation, and receptor-interacting protein-1 activation. Further, SE pretreatment decreased Cyp2e1 expression and increased total antioxidant capacity in the liver.
conclusionOur findings demonstrate that prophylactic SE treatment protects mice from APAP-induced hepatotoxicity through modulation of Cyp2e1 expression and antioxidant capacity.
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