ArticleEnvironmental health and preventive medicine2017
Plasma free amino acid profiles evaluate risk of metabolic syndrome, diabetes, dyslipidemia, and hypertension in a large Asian population.
Article in Environmental health and preventive medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.
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Who cites it
49 citing papers in PubMed, 1 synthesis or guideline pooled it, 84 citations in OpenAlex.
- Causal Relationship Between Branched-Chain Amino Acids and Hypertension: A Mendelian Randomization Study.Journal of the American Heart Association · 2024Pooled it
- Human brown fat metabolism associates with systemic branched-chain amino acids homeostasis.Molecular metabolism · 2026Article
- Whole-body and intracellular arginine metabolism in hypertension: role of disease severity and sex.American journal of hypertension · 2026Observational
- Longitudinal Study of Plasma Metabolites During Menopause and Their Associations With Later Onset of Metabolic Syndrome.The Journal of clinical endocrinology and metabolism · 2026Article
- Plasma branched-chain amino acids in chronic kidney disease: associations with atherogenic lipids and mortality.Amino acids · 2026Article
- Article
- Prospective association between plasma amino acids and three Multimorbidity patterns in older adults.Scientific reports · 2025Article
- The associations between circulating amino acids and arterial aneurysms and dissection: A bidirectional Mendelian randomization study.International journal of cardiology. Cardiovascular risk and prevention · 2025Article
- Proline exacerbates hepatic gluconeogenesis via paraspeckle-dependent mRNA retention.Nature metabolism · 2025Article
- Article
- Association Between Thyroid Function Parameters and Plasma Branched-Chain Amino and Keto Acids in Patients With Euthyroid Type 2 Diabetes Mellitus.Journal of diabetes research · 2025Article
- The inverse associations of glycine and histidine in diet with hyperlipidemia and hypertension.Nutrition journal · 2024Article
- Branched-chain amino acids and the risk of hypertension; a persian cohort-based study.BMC cardiovascular disorders · 2024Article
- Duality of Branched-Chain Amino Acids in Chronic Cardiovascular Disease: Potential Biomarkers versus Active Pathophysiological Promoters.Nutrients · 2024Review
- Serum branch chain amino acids and aromatic amino acids ratio and metabolic risks in Koreans with normal-weight or obesity: a cross-sectional study.Korean journal of community nutrition · 2024Article
- Dietary amino acid profile and risk of hypertension: findings from the Ravansar cohort study.BMC nutrition · 2024Article
- Dietary branched-chain amino acids intake and new-onset hypertension: a nationwide prospective cohort study in China.Amino acids · 2024Article
- Branched-chain amino acid supplementation and voluntary running have distinct effects on the serum metabolome of rats with high or low intrinsic aerobic capacity.Frontiers in nutrition · 2024Article
- The association between dietary amino acid profile and the risk of type 2 diabetes: Ravansar non-communicable disease cohort study.BMC public health · 2023Article
- A metabolomics-based analysis of the metabolic pathways associated with the regulation of branched-chain amino acids in rats fed a high-fructose diet.Endocrine connections · 2023Article
Corrections and comments
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Authors and funding
18 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecently, the association of plasma free amino acid (PFAA) profile and lifestyle-related diseases has been reported. However, few studies have been reported in large Asian populations, about the usefulness of PFAAs for evaluating disease risks. We examined the ability of PFAA profiles to evaluate lifestyle-related diseases in so far the largest Asian population.
methodsWe examined plasma concentrations of 19 amino acids in 8589 Japanese subjects, and determined the association with variables associated with obesity, blood glucose, lipid, and blood pressure. We also evaluated the PFAA indexes that reflect visceral fat obesity and insulin resistance. The contribution of single PFAA level and relevant PFAA indexes was also examined in the risk assessment of lifestyle-related diseases.
resultsOf the 19 amino acids, branched-chain amino acids and aromatic amino acids showed association with obesity and lipid variables. The PFAA index related to visceral fat obesity showed relatively higher correlation with variables than that of any PFAA. In the evaluation of lifestyle-related disease risks, the odds ratios of the PFAA index related to visceral fat obesity or insulin resistance with the diseases were higher than most of those of individual amino acid levels even after adjusting for potential confounding factors. The association pattern of the indexes and PFAA with each lifestyle-related disease was distinct.
conclusionsWe confirmed the usefulness of PFAA profiles and indexes as markers for evaluating the risks of lifestyle-related diseases, including diabetes mellitus, metabolic syndrome, dyslipidemia, and hypertension in a large Asian population.
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