Evidence map›Paper›PMID 29164949›Full record

ArticleInternational journal of immunopathology and pharmacology2017

Local pro-inflammatory cytokine and nitric oxide responses are elevated in patients with pterygium.

S Zidi, F Bediar-Boulaneb, H Belguendouz, M Belkhelfa, O Medjeber, O Laouar, C Henchiri, C Touil-Boukoffa

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of immunopathology and pharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 26 citations in OpenAlex.

  1. Trial
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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

S Zidi1 Department of Biology, University of Guelma, Guelma, Algeria.
F Bediar-Boulaneb4 Department of Ophthalmology, Ibn Rochd University Hospital, Badji Mokhtar University, Annaba, Algeria.
H Belguendouz2 'Cytokines and NO Synthases Team', LBCM, FSB, USTHB, Algiers, Algeria.
M Belkhelfa2 'Cytokines and NO Synthases Team', LBCM, FSB, USTHB, Algiers, Algeria.
O Medjeber2 'Cytokines and NO Synthases Team', LBCM, FSB, USTHB, Algiers, Algeria.
O Laouar5 Department of Anatomopathology, Ibn Rochd University Hospital, Badji Mokhtar University, Annaba, Algeria.
C Henchiri3 Badji Mokhtar University, Annaba, Algeria.
C Touil-Boukoffa2 'Cytokines and NO Synthases Team', LBCM, FSB, USTHB, Algiers, Algeria.
University of Sciences and Technology Houari Boumediene · DZBadji Mokhtar University · DZUniversity of Guelma · DZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pterygium is a common ocular surface disease observed in humans. Chronic ultraviolet (UV) exposure is extensively recognized as an aetiological factor in the pathogenesis of this disease. This hypothesis is sustained by epidemiological and histopathological data in relation to UV injured skin. Although some findings have indicated that genetic factors, anti-apoptotic and immunological mechanisms are involved in the pathogenesis of pterygium, the mechanism by which it develops remains poorly understood. In this study, we analysed the in vivo production of IL-17A, IL-6, IL-10 and nitric oxide (NO) in the tears and sera from Algerian patients. Interestingly, we observed that IL-6, IL-17A and NO production in the tears and sera of all patients was strongly associated with inflammatory infiltration, NOS2, NF-κB and Bcl2 expression in pterygia biopsies. Collectively, our results indicate a relationship between local inflammation and anti-apoptotic processes in pterygium disease, leading to both tissue damage and enhanced cellular proliferation.

Indexed as

AdultConjunctivaFemaleHumansInterleukin-10Interleukin-17Interleukin-6MaleMiddle AgedNF-kappa BNitric OxideNitric Oxide Synthase Type IIProto-Oncogene Proteins c-bcl-2PterygiumTearsBCL2 protein, humanIL10 protein, humanIL17A protein, humanIL6 protein, humanInterleukin-10Interleukin-17Interleukin-6NF-kappa BNitric OxideNitric Oxide Synthase Type IINOS2 protein, humanProto-Oncogene Proteins c-bcl-2cytokinesinflammationNO synthasepterygium

Identifiers

PMID29164949
PMCPMC5806814
OpenAlexW2769149365

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.