ReviewImmunity, inflammation and disease2018
Immunoglobulin G; structure and functional implications of different subclass modifications in initiation and resolution of allergy.
Review in Immunity, inflammation and disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 58 citations in OpenAlex.
- Seroprevalence of anti-SARS-CoV-2 antibodies in COVID-19 patients and healthy volunteers up to 6 months post disease onset.European journal of immunology · 2020Trial
- Serum PLA2R-IgG4/PLA2R-IgG ratio dynamics reveal pathogenic autoantibody subclass switch during progression of PLA2R-associated membranous nephropathy.Annals of medicine · 2026Article
- Label-Free Profiling of Immunoglobulin Isotypes Using Solid-State Nanopores.Small methods · 2026Article
- Characterization of Th2 Serum Immune Response in Acute Appendicitis.International journal of molecular sciences · 2026Article
- Study of the mechanism of methyltransferase 3 regulation of ferroptosis in allergic rhinitis and promotion of allergic rhinitis in an m6A-dependent mechanism.Journal of inflammation (London, England) · 2025Article
- Seasonal variation in respiratory syncytial virus-specific IgG concentrations in Northern Plains American Indian children with asthma.The journal of allergy and clinical immunology. Global · 2025Article
- Children with recurrent infections: perspective of immunoglobulin G subclasses deficiency and impaired specific antibody responses.Clinical and experimental immunology · 2025Review
- Association between allergic rhinitis and development of autoimmune thyroid diseases in Egyptian patients.BMC endocrine disorders · 2024Article
- Scabies: Immunopathogenesis and pathological changes.Parasitology research · 2024Review
- Streamlined Multi-Attribute Assessment of an Array of Clinical-Stage Antibodies: Relationship Between Degradation and Stability.Applied spectroscopy · 2024Article
- Food-specific IgG4-guided diet elimination improves allergy symptoms in children.Frontiers in immunology · 2024Article
- Enhancing the Sensitivity of Lateral Flow Assay with Europium Nanoparticles for Accurate Human IgG Quantification.Micromachines · 2023Article
- Defining Biomarkers to Predict Natural Resolution in Shrimp Allergy.Allergy, asthma & immunology research · 2022Article
- Eosinophil-mediated lung inflammation associated with elevated natural killer T cell response in COVID-19 patients.The Korean journal of internal medicine · 2022Article
- Fungal allergic sensitisation in young rural Zimbabwean children: Gut mycobiome and seroreactivity characteristics.Current research in microbial sciences · 2021Article
- Article
- Antibody Class(es) Predictor for Epitopes (AbCPE): A Multi-Label Classification Algorithm.Frontiers in bioinformatics · 2021Article
- Biochemical, hematological and immunological parameters and relationship with occupational exposure to pesticides and metals.Environmental science and pollution research international · 2020Article
- Adjuvant Activity of Synthetic Lipid A ofVaccines · 2020Article
- Efficacy of long-term treatment with omalizumab in a food and inhalant allergy patient.Postepy dermatologii i alergologii · 2020Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
IgE and not IgG is usually associated with allergy. IgE lodged on mast cells in skin or gut and basophils in the blood allows for the prolonged duration of allergy through the persistent expression of high affinity IgE receptors. However, many allergic reactions are not dependent on IgE and are generated in the absence of allergen specific and even total IgE. Instead, IgG plasma cells are involved in induction of, and for much of the pathogenesis of, allergic diseases. The pattern of IgG producing plasma cells in atopic children and the tendency for direct or further class switching to IgE are the principle factors responsible for long-lasting sensitization of mast cells in allergic children. Indirect class switching from IgG producing plasma cells has been shown to be the predominant pathway for production of IgE while a Th2 microenvironment, genetic predisposition, and the concentration and nature of allergens together act on IgG plasma cells in the atopic tendency to undergo further immunoglobulin gene recombination. The seminal involvement of IgG in allergy is further indicated by the principal role of IgG4 in the natural resolution of allergy and as the favourable immunological response to immunotherapy. This paper will look at allergy through the role of different antibodies than IgE and give current knowledge of the nature and role of IgG antibodies in the start, maintenance and resolution of allergy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.