Evidence map›Paper›PMID 29164814›Full record

ArticleArthritis & rheumatology (Hoboken, N.J.)2018

Detection of Subclinical Arthritis in Mice by a Thrombin Receptor-Derived Imaging Agent.

Beth Friedman, Michael A Whitney, Elamprakash N Savariar, Christa Caneda, Paul Steinbach, Qing Xiong, Dina V Hingorani, Jessica Crisp, Stephen R Adams, Michael Kenner and 5 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Arthritis & rheumatology (Hoboken, N.J.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 1 institution in 1 country.

Beth FriedmanUniversity of California at San Diego, La Jolla, California.
Michael A WhitneyUniversity of California at San Diego, La Jolla, California.
Elamprakash N SavariarUniversity of California at San Diego, La Jolla, California.
Christa CanedaUniversity of California at San Diego, La Jolla, California.
Paul SteinbachUniversity of California at San Diego, La Jolla, California.
Qing XiongUniversity of California at San Diego, La Jolla, California.
Dina V HingoraniUniversity of California at San Diego, La Jolla, California.
Jessica CrispUniversity of California at San Diego, La Jolla, California.
Stephen R AdamsUniversity of California at San Diego, La Jolla, California.
Michael KennerUniversity of California at San Diego, La Jolla, California.
Csilla N LippertUniversity of California at San Diego, La Jolla, California.
Quyen T NguyenUniversity of California at San Diego, La Jolla, California.
Monica GumaUniversity of California at San Diego, La Jolla, California.
Roger Y TsienUniversity of California at San Diego, La Jolla, California.
Maripat CorrUniversity of California at San Diego, La Jolla, California.
University of California, San Diego · US

Funding

U of Calif, San Diego Neuroscience Microscopy ImagingP30NS047101 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GLEESON, JOSEPH G, ZHENG, BINHAI · 2003 to 2022
$9.0M
Resilient versus fragile aspects of blood flow in the mammalian brainR35NS097265 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KLEINFELD, DAVID · 2017 to 2024
$6.8M
DYNAMICS OF SIGNAL TRANSDUCTION IN NEURONSR01NS027177 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ADAMS, STEPHEN ROY, ELLISMAN, MARK H · 1989 to 2017
$5.8M
DYNAMICS OF SIGNAL TRANSDUCTION IN NEURONSR37NS027177 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TSIEN, ROGER Y · 2007 to 2013
$4.8M
Injectable reporters to image tumors and guide resectionR01CA158448 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI NGUYEN, QUYEN · 2011 to 2015
$3.1M
Choline kinase: a novel target for rheumatoid arthritisK08AR064834 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GUMA, MONICA · 2013 to 2017
$687k
Howard Hughes Medical InstituteNCI NIH HHS R01 CA158448NIAMS NIH HHS K08 AR064834NINDS NIH HHS P30 NS047101NINDS NIH HHS R01 NS027177NINDS NIH HHS R35 NS097265NINDS NIH HHS R37 NS027177
6 · The paper itself

Abstract

objectiveFunctional imaging of synovitis could improve both early detection of rheumatoid arthritis (RA) and long-term outcomes. Given the intersection of inflammation with coagulation protease activation, this study was undertaken to examine coagulation protease activities in arthritic mice with a dual-fluorescence ratiometric activatable cell-penetrating peptide (RACPP) that has a linker, norleucine (Nle)-TPRSFL, with a cleavage site for thrombin.

methodsK/BxN-transgenic mice with chronic arthritis and mice with day 1 passive serum-transfer arthritis were imaged in vivo for Cy5:Cy7 emission ratiometric fluorescence from proteolytic cleavage and activation of RACPP

resultsIn chronic arthritis, RACPP

conclusionRACPP

Indexed as

AnimalsArthritis, ExperimentalBiomarkersDisease Models, AnimalFemaleMaleMiceMice, Inbred C57BLMice, TransgenicOptical ImagingReceptors, ThrombinThrombinBiomarkersReceptors, ThrombinThrombin

Identifiers

PMID29164814
PMCPMC5745304
OpenAlexW2768374073

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.