ArticleHuman brain mapping2018
Task-related changes in degree centrality and local coherence of the posterior cingulate cortex after major cardiac surgery in older adults.
Article in Human brain mapping, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 31 citations in OpenAlex.
- Trial
- Postoperative changes in cognition and cerebrospinal fluid neurodegenerative disease biomarkers.Annals of clinical and translational neurology · 2022Trial
- Prediction of postoperative visual cognitive impairment using graph theory and machine learning based on resting-state brain networks.BMC medical imaging · 2025Article
- Predilection for Perplexion: Preoperative microstructural damage is linked to postoperative delirium.medRxiv : the preprint server for health sciences · 2025Article
- Cognitive and Cerebrospinal Fluid Alzheimer's Disease-related Biomarker Trajectories in Older Surgical Patients and Matched Nonsurgical Controls.Anesthesiology · 2024Article
- Inflammation Disrupts the Brain Network of Executive Function after Cardiac Surgery.Annals of surgery · 2023Article
- Regional cerebral hypometabolism on 18F-FDG PET/CT scan in delirium is independent of acute illness and dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Article
- Different whole-brain functional connectivity correlates of reactive-proactive aggression and callous-unemotional traits in children and adolescents with disruptive behaviors.NeuroImage. Clinical · 2023Article
- Functional MRI Changes in Patients after Thyroidectomy under General Anesthesia.BioMed research international · 2022Article
- Relationship Between Depression/Anxiety and Cognitive Function Before and 6 Weeks After Major Non-Cardiac Surgery in Older Adults.Journal of geriatric psychiatry and neurology · 2022Observational
- Perioperative neurocognitive and functional neuroimaging trajectories in older APOE4 carriers compared with non-carriers: secondary analysis of a prospective cohort study.British journal of anaesthesia · 2021Article
- Abnormally weak functional connections get stronger in chronic stroke patients who benefit from naming therapy.Brain and language · 2021Article
- Cerebrospinal Fluid Proteome Changes in Older Non-Cardiac Surgical Patients with Postoperative Cognitive Dysfunction.Journal of Alzheimer's disease : JAD · 2021Observational
- Of Parachutes, Speedometers, and EEG: What Evidence Do We Need to Use Devices and Monitors?Anesthesia and analgesia · 2020Article
- Altered spontaneous brain activity pattern in patients with ophthalmectomy: an resting-state fMRI study.International journal of ophthalmology · 2020Article
- A pilot study of neural correlates of perioperative executive function associated with noncardiac surgery in the elderly.British journal of anaesthesia · 2019Article
- State of the clinical science of perioperative brain health: report from the American Society of Anesthesiologists Brain Health Initiative Summit 2018.British journal of anaesthesia · 2019Review
- Premorbid Alterations of Spontaneous Brain Activity in Elderly Patients With Early Post-operative Cognitive Dysfunction: A Pilot Resting-State Functional MRI Study.Frontiers in neurology · 2019Article
- Task-related changes in degree centrality and local coherence of the posterior cingulate cortex after major cardiac surgery in older adults.Human brain mapping · 2018Article
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 1 country.
Funding
Abstract
objectivesOlder adults often display postoperative cognitive decline (POCD) after surgery, yet it is unclear to what extent functional connectivity (FC) alterations may underlie these deficits. We examined for postoperative voxel-wise FC changes in response to increased working memory load demands in cardiac surgery patients and nonsurgical controls. EXPERIMENTAL
designOlder cardiac surgery patients (n = 25) completed a verbal N-back working memory task during MRI scanning and cognitive testing before and 6 weeks after surgery; nonsurgical controls with cardiac disease (n = 26) underwent these assessments at identical time intervals. We measured postoperative changes in degree centrality, the number of edges attached to a brain node, and local coherence, the temporal homogeneity of regional functional correlations, using voxel-wise graph theory-based FC metrics. Group × time differences were evaluated in these FC metrics associated with increased N-back working memory load (2-back > 1-back), using a two-stage partitioned variance, mixed ANCOVA. PRINCIPAL OBSERVATIONS: Cardiac surgery patients demonstrated postoperative working memory load-related degree centrality increases in the left dorsal posterior cingulate cortex (dPCC; p < .001, cluster p-FWE < .05). The dPCC also showed a postoperative increase in working memory load-associated local coherence (p < .001, cluster p-FWE < .05). dPCC degree centrality and local coherence increases were inversely associated with global cognitive change in surgery patients (p < .01), but not in controls.
conclusionsCardiac surgery patients showed postoperative increases in working memory load-associated degree centrality and local coherence of the dPCC that were inversely associated with postoperative global cognitive outcomes and independent of perioperative cerebrovascular damage.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.