ArticlePflugers Archiv : European journal of physiology2018
Relevance of TRPA1 and TRPM8 channels as vascular sensors of cold in the cutaneous microvasculature.
Article in Pflugers Archiv : European journal of physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 46 citations in OpenAlex.
- Hesperetin-7-Nutrients · 2023Trial
- Peripheral skin cooling during gravitational challenges in parabolic flight - experimental protocol, implementation, and case study of the CoolFly experiment.Frontiers in physiology · 2025Article
- Decoding Cold Therapy Mechanisms of Enhanced Bone Repair through Sensory Receptors and Molecular Pathways.Biomedicines · 2024Article
- Unveiling the role of TRPA1 in cardiovascular health and disease: a mini review.Frontiers in cardiovascular medicine · 2024Review
- Reduced menthol sensitivity in a prodromal Parkinson's disease model induced by intranasal rotenone treatment.Frontiers in cellular neuroscience · 2024Article
- The transient receptor potential channels in rheumatoid arthritis: Need to pay more attention.Frontiers in immunology · 2023Review
- Sex differences in thermoregulation in mammals: Implications for energy homeostasis.Frontiers in endocrinology · 2023Review
- Influence of Cold-TRP Receptors on Cold-Influenced Behaviour.Pharmaceuticals (Basel, Switzerland) · 2021Article
- Dysfunctional TRPM8 signalling in the vascular response to environmental cold in ageing.eLife · 2021Article
- Long-Term Sequelae of Frostbite-A Scoping Review.International journal of environmental research and public health · 2021Article
- TRPM8 Channels: Advances in Structural Studies and Pharmacological Modulation.International journal of molecular sciences · 2021Review
- Highly functionalized β-lactams and 2-ketopiperazines as TRPM8 antagonists with antiallodynic activity.Scientific reports · 2020Article
- Current Knowledge on the Vascular Effects of Menthol.Frontiers in physiology · 2020Review
- A Cold Environment Aggravates Cough Hyperreactivity in Guinea Pigs With Cough by Activating the TRPA1 Signaling Pathway in Skin.Frontiers in physiology · 2020Article
- Therapeutic Effect ofEvidence-based complementary and alternative medicine : eCAM · 2020Article
- Expression of TRPM8 in human reactive lymphoid tissues and mature B-cell neoplasms.Oncology letters · 2018Article
- Mammalian cold TRP channels: impact on thermoregulation and energy homeostasis.Pflugers Archiv : European journal of physiology · 2018Review
- Deletion of the Cold Thermoreceptor TRPM8 Increases Heat Loss and Food Intake Leading to Reduced Body Temperature and Obesity in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Cold exposure is directly related to skin conditions, such as frostbite. This is due to the cold exposure inducing a vasoconstriction to reduce cutaneous blood flow and protect against heat loss. However, a long-term constriction will cause ischaemia and potentially irreversible damage. We have developed techniques to elucidate the mechanisms of the vascular cold response. We focused on two ligand-gated transient receptor potential (TRP) channels, namely, the established "cold sensors" TRP ankyrin 1 (TRPA1) and TRP melastin (TRPM8). We used the anaesthetised mouse and measured cutaneous blood flow by laser speckle imaging. Two cold treatments were used. A generalised cold treatment was achieved through whole paw water immersion (10 °C for 5 min) and a localised cold treatment that will be potentially easier to translate to human studies was carried out on the mouse paw with a copper cold probe (0.85-cm diameter). The results show that TRPA1 and TRPM8 can each act as a vascular cold sensor to mediate the vasoconstrictor component of whole paw cooling as expected from our previous research. However, the local cooling-induced responses were only blocked when the TRPA1 and TRPM8 antagonists were given simultaneously. This suggests that this localised cold probe response requires both functional TRPA1 and TRPM8.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.