Evidence map›Paper›PMID 29164271›Full record

ArticleCellular and molecular life sciences : CMLS2018

Bacteriophages targeting intestinal epithelial cells: a potential novel form of immunotherapy.

Andrzej Górski, Ewa Jończyk-Matysiak, Marzanna Łusiak-Szelachowska, Ryszard Międzybrodzki, Beata Weber-Dąbrowska, Jan Borysowski

Open access · hybridAbstract read
In one paragraph

Article in Cellular and molecular life sciences : CMLS, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 31 citations in OpenAlex.

  1. Review
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  9. A Metabolite ofJournal of the American Chemical Society · 2021
    Article
  10. Review
  11. Article
  12. Review
  13. Therapeutic potential of phages in autoimmune liver diseases.Clinical and experimental immunology · 2018
    Review
  14. Article
  15. Phage Therapy in Prostatitis: Recent Prospects.Frontiers in microbiology · 2018
    Review
  16. Phage Therapy: Beyond Antibacterial Action.Frontiers in medicine · 2018
    Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Andrzej GórskiBacteriophage Laboratory, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences (HIIET PAS), 53-114, Wrocław, Poland. agorski@ikp.pl.
Ewa Jończyk-MatysiakBacteriophage Laboratory, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences (HIIET PAS), 53-114, Wrocław, Poland.
Marzanna Łusiak-SzelachowskaBacteriophage Laboratory, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences (HIIET PAS), 53-114, Wrocław, Poland.
Ryszard MiędzybrodzkiBacteriophage Laboratory, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences (HIIET PAS), 53-114, Wrocław, Poland.
Beata Weber-DąbrowskaBacteriophage Laboratory, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences (HIIET PAS), 53-114, Wrocław, Poland.
Jan BorysowskiDepartment of Clinical Immunology, Transplantation Institute, Medical University of Warsaw, 02-006, Warsaw, Poland.
Ludwik Hirszfeld Institute of Immunology and Experimental Therapy · PLMedical University of Warsaw · PLPolish Academy of Sciences · PL

Funding

National Science Center DEC-2013/11/B/NZ1/02107National Science Center DEC-2015/17/N/NZ6/03520
6 · The paper itself

Abstract

In addition to their established role as a physical barrier to invading pathogens and other harmful agents, intestinal epithelial cells (IEC) are actively involved in local immune reactions. In the past years, evidence has accumulated suggesting the role of IEC in the immunopathology of intestinal inflammatory disorders (IBD). Recent advances in research on bacteriophages strongly suggest that-in addition to their established antibacterial activity-they have immunomodulating properties that are potentially useful in the clinic. We suggest that these immunomodulating phage activities targeting IEC may open novel treatment perspectives in disorders of the alimentary tract, particularly IBD.

Indexed as

AnimalsBacteriophagesEpithelial CellsHumansImmunomodulationImmunotherapyInflammatory Bowel DiseasesIntestinal MucosaIntestinesImmunityImmunomodulationIntestinal epithelial cellIntestinal inflammatory disorderPhagePhage therapy

Identifiers

PMID29164271
PMCPMC5769817
OpenAlexW2770291194

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.