ArticleLab on a chip2017
Performing multi-step chemical reactions in microliter-sized droplets by leveraging a simple passive transport mechanism.
Article in Lab on a chip, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed.
- Scalable droplet-based radiosynthesis of [Lab on a chip · 2024Article
- Proof-of-concept optimization of a copper-mediatedLab on a chip · 2023Article
- Accelerating radiochemistry development: Automated robotic platform for performing up to 64 droplet radiochemical reactions in a morning.Chemical engineering journal (Lausanne, Switzerland : 1996) · 2023Article
- Ultrasonic tweezer for multifunctional droplet manipulation.Science advances · 2023Article
- Radiolabeled nanomaterial for cancer diagnostics and therapeutics: principles and concepts.Cancer nanotechnology · 2023Review
- Rapid Purification and Formulation of Radiopharmaceuticals via Thin-Layer Chromatography.Molecules (Basel, Switzerland) · 2022Article
- Droplet motion on a wrinkled PDMS surface with a gradient structural length scale shorter than the droplet diameter.RSC advances · 2022Article
- Economical Production of Radiopharmaceuticals for Preclinical Imaging Using Microdroplet Radiochemistry.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Economical droplet-based microfluidic production of [Scientific reports · 2021Article
- Optimization of Radiochemical Reactions using Droplet Arrays.Journal of visualized experiments : JoVE · 2021Article
- Cerenkov Luminescence Imaging in the Development and Production of Radiopharmaceuticals.Frontiers in physics · 2021Article
- Electrowetting-on-dielectric (EWOD): Current perspectives and applications in ensuring food safety.Journal of food and drug analysis · 2020Review
- A simple and efficient automated microvolume radiosynthesis of [EJNMMI radiopharmacy and chemistry · 2020Article
- The Current Role of Microfluidics in Radiofluorination Chemistry.Molecular imaging and biology · 2020Review
- Multi-GBq production of the radiotracer [RSC advances · 2020Article
- Green and efficient synthesis of the radiopharmaceutical [Reaction chemistry & engineering · 2020Article
- Rapid, efficient, and economical synthesis of PET tracers in a droplet microreactor: application to O-(2-[EJNMMI radiopharmacy and chemistry · 2019Article
- Ultra-compact, automated microdroplet radiosynthesizer.Lab on a chip · 2019Article
- A novel multi-reaction microdroplet platform for rapid radiochemistry optimization.RSC advances · 2019Article
- Automated concentration of [Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Despite the increasing importance of positron emission tomography (PET) imaging in research and clinical management of disease, access to myriad new radioactive tracers is severely limited due to their short half-lives (which requires daily production) and the high cost and complexity of tracer production. The application of droplet microfluidics based on electrowetting-on-dielectric (EWOD) to the field of radiochemistry can significantly reduce the amount of radiation shielding necessary for safety and the amount of precursor and other reagents needed for the synthesis. Furthermore, significant improvements in the molar activity of the tracers have been observed. However, widespread use of this technology is currently hindered in part by the high cost of prototype chips and the operating complexity. To address these issues, we developed a novel microfluidic device based on patterned wettability for multi-step radiochemical reactions in microliter droplets and implemented automated systems for reagent loading and collection of the crude product after synthesis. In this paper, we describe a simple and inexpensive method for fabricating the chips, demonstrate the feasibility of prototype chips for performing multi-step radiochemical reactions to produce the PET tracers [
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.