Evidence map›Paper›PMID 29164133›Full record

ReviewFrontiers in cardiovascular medicine2017

Role of Dietary Antioxidants in the Preservation of Vascular Function and the Modulation of Health and Disease.

Saradhadevi Varadharaj, Owen J Kelly, Rami N Khayat, Purnima S Kumar, Naseer Ahmed, Jay L Zweier

3 registry-linked trialsOpen access · goldAbstract readReview
In one paragraph

Review in Frontiers in cardiovascular medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05795946 naterminatednot on this mapstarted 2023, after this paper: background citation

Effects of a Whole Food Based Nutritional Formulation on Trimethylamine N-oxide and Cardiometabolic Endpoints in Healthy Adults.

TypeinterventionalSponsorStandard Process Inc.Ran2023 to 2024Enrolled14ConditionsNutrition, HealthyArmsWhole food-based B and D vitamins
NCT05877365 nacompletednot on this mapstarted 2023, after this paper: background citation

Effects of Standard Process's 21-day Guided Purification Program on Metabolic Health in College Setting

TypeinterventionalSponsorStandard Process Inc.Ran2023 to 2024Enrolled32ConditionsHealthyArmsStandard Process 21-Day Purification Program
NCT06061289 nacompletednot on this mapstarted 2022, after this paper: background citation

Effects of Standard Process's SP Detox Balance Dietary Supplements on Metabolic Detoxification

TypeinterventionalSponsorStandard Process Inc.Ran2022 to 2022Enrolled32ConditionsDetoxification ResponseArmsSP Detox Program
3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 96 citations in OpenAlex.

  1. Trial
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  6. Microvascular Health as a Key Determinant of Organismal Aging.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Saradhadevi VaradharajAbbott Nutrition, Columbus, OH, United States.
Owen J KellyAbbott Nutrition, Columbus, OH, United States.
Rami N KhayatThe Sleep Heart Program, Division of Pulmonary Critical Care and Sleep, Columbus, OH, United States.
Purnima S KumarCollege of Dentistry, The Ohio State University, Columbus, OH, United States.
Naseer AhmedAbbott Laboratories, Chicago, IL, United States.
Jay L ZweierDivision of Cardiovascular Medicine, Department of Internal Medicine, College of Medicine, Davis Heart & Lung Research Institute, The Ohio State University, Columbus, OH, United States.
Abbott (United States) · USThe Ohio State University · USAbbott Nutrition (United States)

Funding

Role of Cytoglobin in the Regulation of Vascular ToneR01HL131941 · NHLBI · OHIO STATE UNIVERSITY · PI JAY Louis ZWEIER · 2017 to 2026
$5.7M
Mechanisms of Nicotine Inhalation-Induced Cardiovascular DiseaseR01HL135648 · NHLBI · OHIO STATE UNIVERSITY · PI ZWEIER, JAY LOUIS · 2017 to 2021
$2.6M
NHLBI NIH HHS R01 HL131941NHLBI NIH HHS R01 HL135648
6 · The paper itself

Abstract

In vascular diseases, including hypertension and atherosclerosis, vascular endothelial dysfunction (VED) occurs secondary to altered function of endothelial nitric oxide synthase (eNOS). A novel redox regulated pathway was identified through which eNOS is uncoupled due to

Indexed as

antioxidantsblood flowendothelial nitric oxide synthase couplingnitric oxidevascular health

Identifiers

PMID29164133
PMCPMC5671956
OpenAlexW2759190833

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.