Evidence map›Paper›PMID 29164052›Full record

ArticleFrontiers in oncology2017

Development of Novel Patient-Derived Xenografts from Breast Cancer Brain Metastases.

María J Contreras-Zárate, D Ryan Ormond, Austin E Gillen, Colton Hanna, Nicole L Day, Natalie J Serkova, Britta M Jacobsen, Susan M Edgerton, Ann D Thor, Virginia F Borges and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 39 citations in OpenAlex.

  1. Review
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  5. Review
  6. Mucin 5AC Promotes Breast Cancer Brain Metastasis through cMET/CD44v6.Clinical cancer research : an official journal of the American Association for Cancer Research · 2025
    Article
  7. Review
  8. Article
  9. Review
  10. Microglia and metastases to the central nervous system: victim, ravager, or something else?Journal of experimental & clinical cancer research : CR · 2022
    Review
  11. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

María J Contreras-ZárateDepartment of Pathology, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
D Ryan OrmondDepartment of Neurosurgery, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
Austin E GillenRNA Bioscience Initiative, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
Colton HannaDepartment of Pathology, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
Nicole L DayDepartment of Pathology, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
Natalie J SerkovaDepartment of Anesthesiology, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
Britta M JacobsenDepartment of Pathology, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
Susan M EdgertonDepartment of Pathology, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
Ann D ThorDepartment of Pathology, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
Virginia F BorgesDepartment of Medicine, Division of Medical Oncology, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
Kevin O LilleheiDepartment of Neurosurgery, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
Michael W GranerDepartment of Neurosurgery, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
Peter KabosDepartment of Medicine, Division of Medical Oncology, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
Diana M CittellyDepartment of Pathology, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
University of Colorado Anschutz Medical Campus · US

Funding

University of Colorado Cancer Center Support Grant - Lung Cancer Patient-Derived Xenografts with Autologous Human Immune SystemsP30CA046934 · NCI · UNIVERSITY OF COLORADO DENVER · PI James V Degregori · 1988 to 2026
$117.0M
Colorado Clinical and Translational Sciences InstituteUL1TR001082 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2013 to 2017
$48.0M
Cancer-associated fibroblasts in estrogen receptor positive breast cancer.R01CA205044 · NCI · UNIVERSITY OF COLORADO DENVER · PI KABOS, PETER · 2016 to 2020
$1.8M
Regulation of anti-endocrine resistance of breast cancer by a network of non-codiK08CA164048 · NCI · UNIVERSITY OF COLORADO DENVER · PI KABOS, PETER · 2012 to 2016
$859k
IN-VIVO SPECTROSCOPY,IMAGING SYST PHARMASCAN: NUTRITION, LIPID METABOLISMS10RR019316 · NCRR · UNIVERSITY OF COLORADO DENVER · PI SERKOVA, NATALIE J · 2005 to 2005
$498k
Hormonal regulation of the brain microenvironment and its contribution to brain mK22CA181250 · NCI · UNIVERSITY OF COLORADO DENVER · PI CITTELLY, DIANA M. · 2013 to 2015
$422k
NCATS NIH HHS UL1 TR001082NCI NIH HHS K08 CA164048NCI NIH HHS K22 CA181250NCI NIH HHS P30 CA046934NCI NIH HHS R01 CA205044NCRR NIH HHS S10 RR019316
6 · The paper itself

Abstract

Brain metastases are an increasing burden among breast cancer patients, particularly for those with HER2

Indexed as

brain colonizationbrain metastases modelsbreast cancerHER2+patient-derived xenografttriple negative

Identifiers

PMID29164052
PMCPMC5673842
OpenAlexW2765527092

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.