Evidence map›Paper›PMID 29164026›Full record

ArticleGlobal spine journal2017

A Clinical Practice Guideline for the Management of Patients With Acute Spinal Cord Injury: Recommendations on the Type and Timing of Anticoagulant Thromboprophylaxis.

Michael G Fehlings, Lindsay A Tetreault, Bizhan Aarabi, Paul Anderson, Paul M Arnold, Darrel S Brodke, Anthony S Burns, Kazuhiro Chiba, Joseph R Dettori, Julio C Furlan and 23 more

Open access · goldAbstract read
In one paragraph

Article in Global spine journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 54 citations in OpenAlex.

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  14. Guideline for diagnosis and treatment of spine trauma in the epidemic of COVID-19.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2020
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

33 authors at 20 institutions in 6 countries.

Michael G FehlingsToronto Western Hospital, University Health Network, Toronto, Ontario, Canada.
Lindsay A TetreaultToronto Western Hospital, University Health Network, Toronto, Ontario, Canada.
Bizhan AarabiUniversity of Maryland School of Medicine, Baltimore, MD, USA.
Paul AndersonUniversity of Wisconsin, Madison, WI, USA.
Paul M ArnoldThe University of Kansas, Kansas City, KS, USA.
Darrel S BrodkeUniversity of Utah, Salt Lake City, UT, USA.
Anthony S BurnsToronto Rehabilitation Institute, University Health Network, Toronto, Ontario, Canada.
Kazuhiro ChibaNational Defense Medical College, Saitama, Japan.
Joseph R DettoriSpectrum Research, Inc, Tacoma, WA, USA.
Julio C FurlanUniversity of Toronto, Toronto, Ontario, Canada.
Gregory HawrylukUniversity of Utah, Salt Lake City, UT, USA.
Langston T HollyUniversity of California at Los Angeles, Los Angeles, CA, USA.
Susan HowleyChristopher & Dana Reeve Foundation, Short Hills, NJ, USA.
Tara JejiOntario Neurotrauma Foundation, Toronto, Ontario, Canada.
Sukhvinder Kalsi-RyanToronto Western Hospital, University Health Network, Toronto, Ontario, Canada.
Mark KotterUniversity of Cambridge, Cambridge, UK.
Shekar KurpadMedical College of Wisconsin, Milwaukee, WI, USA.
Brian K KwonUniversity of British Columbia, Vancouver, British Columbia, Canada.
Ralph J MarinoThomas Jefferson University Hospital, Philadelphia, PA, USA.
Allan R MartinToronto Western Hospital, University Health Network, Toronto, Ontario, Canada.
Eric MassicotteToronto Western Hospital, University Health Network, Toronto, Ontario, Canada.
Geno MerliSidney Kimmel Medical College, Thomas Jefferson University Hospitals, Philadelphia, PA, USA.
James W MiddletonUniversity of Sydney, Sydney, New South Wales, Australia.
Hiroaki NakashimaNagoya University Graduate School of Medicine, Nagoya, Japan.
Narihito NagoshiToronto Western Hospital, University Health Network, Toronto, Ontario, Canada.
Katherine PalmieriThe University of Kansas, Kansas City, KS, USA.
Anoushka SinghToronto Western Hospital, University Health Network, Toronto, Ontario, Canada.
Andrea C SkellySpectrum Research, Inc, Tacoma, WA, USA.
Eve C TsaiUniversity of Ottawa, Ottawa, Ontario, Canada.
Alexander VaccaroThomas Jefferson University, Philadelphia, PA, USA.
Jefferson R WilsonUniversity of Toronto, Toronto, Ontario, Canada.
Albert YeeSunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
James S HarropThomas Jefferson University, Philadelphia, PA, USA.
University Health Network · CASpectrum Research (United States) · USThomas Jefferson University · USThomas Jefferson University Hospital · USToronto Western Hospital · CAUniversity of Kansas · USUniversity of Toronto · CAUniversity of Utah · USChristopher and Dana Reeve Foundation · USHealth Sciences Centre · CAMedical College of Wisconsin · USNagoya University · JPNational Defense Medical College · JPOntario Neurotrauma Foundation · CASt. Michael's Hospital · CAThe University of Sydney · AUUniversity College Cork · IEUniversity of British Columbia · CAUniversity of California, Los Angeles · USUniversity of Cambridge · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe objective of this study is to develop evidence-based guidelines that recommend effective, safe and cost-effective thromboprophylaxis strategies in patients with spinal cord injury (SCI).

methodsA systematic review of the literature was conducted to address key questions relating to thromboprophylaxis in SCI. Based on GRADE (Grading of Recommendation, Assessment, Development and Evaluation), a strong recommendation is worded as "we recommend," whereas a weaker recommendation is indicated by "we suggest."

resultsBased on conclusions from the systematic review and expert panel opinion, the following recommendations were developed: (1) "We suggest that anticoagulant thromboprophylaxis be offered routinely to reduce the risk of thromboembolic events in the acute period after SCI;" (2) "We suggest that anticoagulant thromboprophylaxis, consisting of either subcutaneous low-molecular-weight heparin or fixed, low-dose unfractionated heparin (UFH) be offered to reduce the risk of thromboembolic events in the acute period after SCI. Given the potential for increased bleeding events with the use of adjusted-dose UFH, we suggest against this option;" (3) "We suggest commencing anticoagulant thromboprophylaxis within the first 72 hours after injury, if possible, in order to minimize the risk of venous thromboembolic complications during the period of acute hospitalization."

conclusionsThese guidelines should be implemented into clinical practice in patients with SCI to promote standardization of care, decrease heterogeneity of management strategies and encourage clinicians to make evidence-informed decisions.

Indexed as

acute spinal cord injuryanticoagulantanticoagulant thromboprophylaxisguidelinespinal cord injurythromboprophylaxistraumatic spinal cord injury

Identifiers

PMID29164026
PMCPMC5684841
OpenAlexW2750998856

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.