Evidence map›Paper›PMID 29163982›Full record

ArticleBJPsych open2017

Individual differences in schizophrenia.

Edmund T Rolls, Wenlian Lu, Lin Wan, Hao Yan, Chuanyue Wang, Fude Yang, Yunlong Tan, Lingjiang Li, Chinese Schizophrenia Collaboration Group, Hao Yu and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BJPsych open, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Edmund T Rolls, MA, DPhil, DSc, Department of Computer Science, University of Warwick, Coventry, UK; Oxford Centre for Computational Neuroscience, Oxford, UK.
Wenlian LuPhD, Centre for Computational Systems Biology, Fudan University, Shanghai, PR China.
Lin Wan, PhD, National Center for Mathematics and Interdisciplinary Sciences, The Key Laboratory of Systems and Control, Academy of Mathematics and Systems Science, Chinese Academy of Sciences, Beijing, PR China.
Hao Yan, MD, Institute of Mental Health, the Sixth Hospital, Peking University, Beijing, PR China; Key Laboratory of Mental Health, Ministry of Health & National Clinical Research Center for Mental Disorders, Peking University, Beijing, PR China.
Chuanyue Wang, MD, Beijing Anding Hospital, Capital Medical University, Beijing, PR China.
Fude Yang, M.M., Beijing HuiLongGuan Hospital, Peking University, Beijing, PR China.
Yunlong Tan, Beijing HuiLongGuan Hospital, Peking University, Beijing, PR China.
Lingjiang Li, MD, Institute of Mental Health, The Second Xiangya Hospital of Central South University, Changsha, PR China.
Chinese Schizophrenia Collaboration Group
Hao Yu, PhD, Institute of Mental Health, the Sixth Hospital, Peking University, Beijing, PR China; Key Laboratory of Mental Health, Ministry of Health & National Clinical Research Center for Mental Disorders, Peking University, Beijing, PR China.
Peter F Liddle, MBBS, MRCPsych, PhD, Centre for Translational Neuroimaging, Institute of Mental Health, Division of Psychiatry & Applied Psychology, University of Nottingham, Nottingham, UK; Sir Peter Mansfield MR Centre, University of Nottingham, Nottingham, UK.
Lena Palaniyappan, MBBS, PhD, Department of Psychiatry, University of Western Ontario, London, Ontario, Canada; Department of Medical Biophysics, University of Western Ontario, London, Ontario, Canada; Robarts & Lawson Health Research Institutes, London, Ontario, Canada.
Dai Zhang, MD, Institute of Mental Health, the Sixth Hospital, Peking University, Beijing, PR China; Key Laboratory of Mental Health, Ministry of Health & National Clinical Research Center for Mental Disorders, Peking University, Beijing, PR China; Peking-Tsinghua Joint Center for Life Sciences/PKU-IDG/McGovern Institute for Brain Research, Peking University, Beijing, China.
Weihua Yue, MD, Institute of Mental Health, the Sixth Hospital, Peking University, Beijing, PR China; Key Laboratory of Mental Health, Ministry of Health & National Clinical Research Center for Mental Disorders, Peking University, Beijing, PR China.
Jianfeng Feng, PhD, Department of Computer Science, University of Warwick, Coventry, UK.

Funding

Medical Research Council MR/K020803/1
6 · The paper itself

Abstract

backgroundWhether there are distinct subtypes of schizophrenia is an important issue to advance understanding and treatment of schizophrenia.

aimsTo understand and treat individuals with schizophrenia, the aim was to advance understanding of differences between individuals, whether there are discrete subtypes, and how first-episode patients (FEP) may differ from multiple episode patients (MEP).

methodThese issues were analysed in 687 FEP and 1880 MEP with schizophrenia using the Positive and Negative Syndrome Scale for (PANSS) schizophrenia before and after antipsychotic medication for 6 weeks.

resultsThe seven Negative Symptoms were correlated with each other and with P2 (conceptual disorganisation), G13 (disturbance of volition), and G7 (motor retardation). The main difference between individuals was in the cluster of seven negative symptoms, which had a continuous unimodal distribution. Medication decreased the PANSS scores for all the symptoms, which were similar in the FEP and MEP groups.

conclusionsThe negative symptoms are a major source of individual differences, and there are potential implications for treatment. DECLARATION OF INTERESTS: L.P. received speaker fees from Otsuka Canada and educational grant from Janssen Canada in 2017. COPYRIGHT AND USAGE: © The Royal College of Psychiatrists 2017. This is an open access article distributed under the terms of the Creative Commons Non-Commercial, No Derivatives (CC BY-NC-ND) license.

Identifiers

PMID29163982
PMCPMC5676076

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.