ReviewBasic and clinical andrology2017
On the descent of the epididymo-testicular unit, cryptorchidism, and prevention of infertility.
Review in Basic and clinical andrology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 60 citations in OpenAlex.
- Comprehensively exploring the roles of MAGEA1 in cryptorchidism and its related transcription factor regulatory network.Journal of molecular histology · 2026Article
- Cryptorchidism and infertility: what do we know so far?Asian journal of andrology · 2026Review
- Age at diagnosis of undescended testis and associated factors in pediatric patients in a tertiary hospital.BMC pediatrics · 2026Article
- Abnormal H3K27me3 underlies degenerative spermatogonial stem cells in cryptorchid testis.Development (Cambridge, England) · 2025Article
- External pressure induces the dysfunction of spermatogonia via triggering the intrinsic pathway of apoptosis.Translational andrology and urology · 2024Article
- Surgical treatment of cryptorchidism: current insights and future directions.Frontiers in endocrinology · 2024Review
- Commentary: The fate of germ cells in cryptorchid testis.Frontiers in endocrinology · 2024Article
- Stepwise mini-incision microdissection testicular sperm extraction in NOA patients with a history of cryptorchidism: a case-control study.Basic and clinical andrology · 2023Article
- Azoospermic Men with a History of Cryptorchidism Treated by Orchiopexy Have Favorable Outcomes after Testicular Sperm Extraction: A Systematic Review and Meta-Analysis.The world journal of men's health · 2023Article
- A novel role for CFTR interaction with LH and FGF in azoospermia and epididymal maldevelopment caused by cryptorchidism.Basic and clinical andrology · 2022Review
- Comparative study of testicular volume in children with unilateral cryptorchidism of different ages in the tropical province of China.International urology and nephrology · 2022Article
- Temperature is not a major factor in the differentiation of gonocytes into ad spermatogonia and fertility outcome in congenitally cryptorchid boys.Basic and clinical andrology · 2022Review
- Gubernaculum and Epididymo-Testicular Descent: Review of the Literature.Acta medica Lituanic · 2022Review
- Review
- Viral infections that alter estrogen levels during pregnancy may contribute to the etiology of cryptorchidism.Basic and clinical andrology · 2021Article
- Molecular clues in the regulation of mini-puberty involve neuronal DNA binding transcription factor NHLH2.Basic and clinical andrology · 2021Review
- Comparison of Two Types of Staged Laparoscopic Orchiopexy for High Intra-Abdominal Testes in Children: A Retrospective Study From a Single Center.Frontiers in pediatrics · 2021Article
- Development of a putative adverse outcome pathway network for male rat reproductive tract abnormalities with specific considerations for the androgen sensitive window of development.Current research in toxicology · 2021Article
- Article
- [Andrological diagnostics prior to treatment by assisted reproduction].Der Urologe. Ausg. A · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This comprehensive review provides in-depth coverage of progress made in understanding the molecular mechanisms underlying cryptorchidism, a frequent pathology first described in about 1786 by John Hunter. The first part focuses on the physiology, embryology, and histology of epididymo-testicular descent. In the last 20 years epididymo-testicular descent has become the victim of schematic drawings with an unjustified rejection of valid histological data. This part also includes discussion on the roles of gonadotropin-releasing hormone, fibroblast growth factors, Müllerian inhibiting substance, androgens, inhibin B, and insulin-like 3 in epididymo-testicular descent. The second part addresses the etiology and histology of cryptorchidism as well as the importance of mini-puberty for normal fertility development. A critical view is presented on current clinical guidelines that recommend early orchidopexy alone as the best possible treatment. Finally, by combining classical physiological information and the output of cutting-edge genomics data into a complete picture the importance of hormonal treatment in preventing cryptorchidism-induced infertility is underscored.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.