ArticleUnited European gastroenterology journal2017
Capsule endoscopy in young patients with iron deficiency anaemia and negative bidirectional gastrointestinal endoscopy.
Article in United European gastroenterology journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Guideline
- Antithrombotic Treatment Is Associated with Small-Bowel Video Capsule Endoscopy Positive Findings in Obscure Gastrointestinal Bleeding: A Systematic Review and Meta-Analysis.Digestive diseases and sciences · 2019Pooled it
- Article
- Article
- The Role of Capsule Endoscopy in the Diagnosis and Management of Small Bowel Tumors: A Narrative Review.Cancers · 2024Review
- Small bowel lesions in patients with iron deficiency anaemia without overt bleeding: a multicentre study.Annals of hematology · 2024Article
- Predictive Model for Positive Video Capsule Endoscopy in Iron Deficiency Anemia.Digestive diseases and sciences · 2023Article
- Octa-nonagenarians can perform video capsule endoscopy safely and with a higher diagnostic yield than 65-79-year-old patients.Journal of the American Geriatrics Society · 2022Article
- Clinical features of capsule endoscopy in young adults: A single-center retrospective study.JGH open : an open access journal of gastroenterology and hepatology · 2022Article
- Video capsule endoscopy in patients with iron deficiency anaemia: experience at a regional Australian service.BMC research notes · 2022Article
- Small Bowel Malignancies in Patients Undergoing Capsule Endoscopy for Iron Deficiency Anemia.Diagnostics (Basel, Switzerland) · 2021Review
- Clinical Impact of Small Bowel Capsule Endoscopy in Obscure Gastrointestinal Bleeding.Medicina (Kaunas, Lithuania) · 2020Article
- AGA Technical Review on Gastrointestinal Evaluation of Iron Deficiency Anemia.Gastroenterology · 2020Review
- Benefit of Capsule Endoscopy in the Setting of Iron Deficiency Anemia in Patients Above Age 65.Journal of the Canadian Association of Gastroenterology · 2020Article
- Small-Bowel Capsule Endoscopy in Clinical Practice: Has Anything Changed Over 13 Years?Digestive diseases and sciences · 2018Article
- Angioectasias in the elderly: Interpreting the data by Pérez-Cuadrado Robles et al.United European gastroenterology journal · 2018Article
- Angioectasias in the elderly: Interpreting the data.United European gastroenterology journal · 2018Article
- Bleeding Lesion of the Small Bowel: an Extensive Update Leaving No Stone Unturned.Current gastroenterology reports · 2018Review
- Fecal calprotectin for detection of postoperative endoscopic recurrence in Crohn's disease: systematic review and meta-analysis.Therapeutic advances in gastroenterology · 2018Article
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Authors and funding
43 authors at 20 institutions in 13 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecent data imply young patients (age ≤50 years) undergoing small-bowel (SB) capsule endoscopy (CE) for iron deficiency anaemia (IDA) show higher diagnostic yield (DY) for sinister pathology. We aimed to investigate DY of CE in a large cohort of young IDA patients, and evaluate factors predicting significant SB pathology. MATERIALS AND
methodsThis was a retrospective, multicentre study (2010-2015) in consecutive, young patients (≤50 years) from 18 centres/12 countries, with negative bidirectional gastrointestinal (GI) endoscopy undergoing SBCE for IDA. Exclusion criteria: previous/ongoing obscure-overt GI bleeding; age <19 or >50 years; comorbidities associated with IDA. Data retrieved: SBCE indications; prior investigations; medications; SBCE findings; final diagnosis. Clinical and laboratory data were analysed by multivariate logistic regression.
resultsData on 389 young IDA patients were retrieved. In total, 169 (43.4%) were excluded due to incomplete clinical data; data from 220 (122F/98M; mean age 40.5 ± 8.6 years) patients were analysed. Some 71 patients had at least one clinically significant SBCE finding (DY: 32.3%). They were divided into two groups: neoplastic pathology (10/220; 4.5%), and non-neoplastic but clinically significant pathology (61/220; 27.7%). The most common significant but non-neoplastic pathologies were angioectasias (22/61) and Crohn's disease (15/61). On multivariate analysis, weight loss and lower mean corpuscular volume(MCV) were associated with significant SB pathology (OR: 3.87; 95%CI: 1.3-11.3;
conclusionIn IDA patients ≤50 years with negative bidirectional GI endoscopy, overall DY of SBCE for clinically significant findings was 32.3%. Some 5% of our cohort was diagnosed with SB neoplasia; lower MCV or weight loss were associated with higher DY for SB pathology.
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