ArticleJournal of vascular and interventional neurology2017
Comparison of Endovascular Treatment with Intravenous Thrombolysis for Isolated M2 Segment of Middle Cerebral Artery Occlusion in Acute Ischemic Stroke.
Article in Journal of vascular and interventional neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 6 syntheses or guidelines pooled it, 13 citations in OpenAlex.
- Endovascular therapy versus best medical care for acute ischemic stroke with distal medium vessel occlusion: a systematic review and meta-analysis.Annals of medicine · 2025Pooled it
- Endovascular thrombectomy for distal medium vessel occlusion stroke: A meta-analysis of randomized controlled trials.Neurosurgical review · 2025Pooled it
- Distal medium vessel occlusions in acute ischaemic stroke - Stent retriever versus direct aspiration: A systematic review and meta-analysis.European stroke journal · 2023Pooled it
- Endovascular treatment versus intravenous thrombolysis alone in isolated M2 occlusion: a meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021Pooled it
- Efficacy and safety of mechanical thrombectomy for M2 segment of middle cerebral artery: a systematic review and meta-analysis.Journal of neurology · 2021Pooled it
- Pooled it
- Endovascular thrombectomy for stroke due to medium vessel occlusion: a meta-analysis of randomized controlled trials.Annals of medicine and surgery (2012) · 2026Article
- Endovascular Therapy Versus Nonendovascular Therapy for Acute Ischemic Stroke With Distal Medium Vessel Occlusion: A Systematic Review and Meta-Analysis.Stroke (Hoboken, N.J.) · 2026Article
- Comparing the Efficacy and Safety of Endovascular Therapy Versus Best Medical Treatment in Acute Ischemic Stroke Patients With Distal Medium Vessel Occlusion: A Systematic Review and Meta-Analysis.Journal of central nervous system disease · 2026Review
- Endovascular Therapy for Isolated M2 Occlusion in Patients with Ischemic Stroke: A Propensity Score-Matched Analysis.Cerebrovascular diseases extra · 2026Article
- Article
- Review
- Mechanical thrombectomy for acute ischemic stroke with occlusion of the M2 segment of the middle cerebral artery: A literature review.Journal of cerebrovascular and endovascular neurosurgery · 2021Article
- The Natural History and Reperfusion Therapy Outcomes of Acute Ischemic Stroke due to Isolated M2 Occlusions.BioMed research international · 2021Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe benefit of endovascular treatment for distal large artery ischemic occlusions such as M2 segment of middle cerebral artery is not clear.
methodsWe retrospectively analyzed data from 51 subjects who had an isolated M2 segment occlusion on baseline computed tomographic (CT) angiogram who were randomized to either intravenous (IV) recombinant tissue plasminogen activator (rt-PA) followed by endovascular treatment or IV rt-PA alone in a multicenter trial. We determined the effect of endovascular treatment on occurrence of excellent [mRS (modified Rankin scale) scores of 0-1] functional outcomes at three months and any death within 3 and 12 months. We also performed proportional odds logistic regression analysis to compare the distribution of mRS scores between the two groups. Each of the analyses was adjusted for age, baseline Alberta stroke program early CT score strata, and baseline National Institutes of Health Stroke scale score strata.
resultsAt three months, the rate of excellent functional outcome (38.2% versus 17.6%, unadjusted odds ratio 2.9; 95% confidence interval ; 0.7-12.1;
conclusionIn this post-hoc analysis, acute ischemic stroke subjects who had isolated M2 segment occlusion randomized to endovascular treatment appeared to have lower mortality and a trend toward lower grades of disability.
Identifiers
29163743PMC5683020W2789915999What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.