Evidence map›Paper›PMID 29163738›Full record

ArticleJournal of clinical medicine research2017

A Case of Moderate Sprue-Like Enteropathy Associated With Telmisartan.

Aurelio Negro, Loredana De Marco, Valentina Cesario, Rosaria Santi, Maria Chiara Boni, Magda Zanelli

Open access · diamondAbstract readCase Reports
In one paragraph

Article in Journal of clinical medicine research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Telmisartan-induced sprue-like enteropathy: a case report.European journal of hospital pharmacy : science and practice · 2020
    Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Sprue-Like Enteropathy and Liver Injury: A Rare Emerging Association with Olmesartan.Journal of investigative medicine high impact case reports
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Aurelio NegroInternal Medicine, Specialized Center of Secondary Hypertension and Gastroenterology, IRCCS-Arcispedale Santa Maria Nuova, Reggio Emilia, Italy.
Loredana De MarcoUnit of Pathology, Department of Oncology and Advanced Technologies, IRCCS-Arcispedale Santa Maria Nuova, Reggio Emilia, Italy.
Valentina CesarioInternal Medicine, Specialized Center of Secondary Hypertension and Gastroenterology, IRCCS-Arcispedale Santa Maria Nuova, Reggio Emilia, Italy.
Rosaria SantiInternal Medicine, Specialized Center of Secondary Hypertension and Gastroenterology, IRCCS-Arcispedale Santa Maria Nuova, Reggio Emilia, Italy.
Maria Chiara BoniInternal Medicine, Specialized Center of Secondary Hypertension and Gastroenterology, IRCCS-Arcispedale Santa Maria Nuova, Reggio Emilia, Italy.
Magda ZanelliUnit of Pathology, Department of Oncology and Advanced Technologies, IRCCS-Arcispedale Santa Maria Nuova, Reggio Emilia, Italy.
Ospedale Santa Maria · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sprue-like enteropathy associated with olmesartan medoxomil use has been recently reported. Its clinical manifestations include diarrhea, weight loss and malabsorption. Duodenal biopsies show villous atrophy (VA) with or without intraepithelial lymphocytosis and inflammation of the lamina propria. Serology for celiac disease (CD) is negative and gluten-free diet does not result in clinical improvement. Symptoms resolve after olmesartan discontinuation. Follow-up biopsies show recovery/improvement of the duodenum. Whether sprue-like enteropathy is a specific adverse reaction to olmesartan or rather a class effect of angiotensin-receptor blockers (ARBs) remains a controversial issue. We report a case of sprue-like enteropathy associated with telmisartan. A 52-year-old man presented with chronic diarrhea, abdominal discomfort and significant weight loss. In the last 3 years, he had been treated with telmisartan 40 mg/day for hypertension after right adrenalectomy for an aldosterone-producing adenoma. Laboratory investigations showed no significant abnormalities: Hb 13.6 g/dL, serum albumin 3.9 g/dL, total cholesterol 193 mg/dL, serum creatinine 0.99 mg/dL, sodium 143.6 mmol/L, K

Indexed as

Sprue-like enteropathyTelmisartan

Identifiers

PMID29163738
PMCPMC5687909
OpenAlexW2765476131

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.