Evidence map›Paper›PMID 29163590›Full record

ArticleFrontiers in plant science2017

Multiple Copies of a Simple MYB-Binding Site Confers Trans-regulation by Specific Flavonoid-Related R2R3 MYBs in Diverse Species.

Cyril Brendolise, Richard V Espley, Kui Lin-Wang, William Laing, Yongyan Peng, Tony McGhie, Supinya Dejnoprat, Sumathi Tomes, Roger P Hellens, Andrew C Allan

Open access · goldAbstract read
In one paragraph

Article in Frontiers in plant science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 46 citations in OpenAlex.

  1. Article
  2. International journal of molecular sciences · 2025
    Article
  3. Article
  4. Article
  5. Genome-Wide Analysis of MYB Transcription Factors and Screening ofInternational journal of molecular sciences · 2023
    Article
  6. Nutritional Component Analyses in Different Varieties ofInternational journal of molecular sciences · 2022
    Article
  7. Article
  8. Defective cytokinin signaling reprograms lipid and flavonoid gene-to-metabolite networks to mitigate high salinity inProceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  9. Article
  10. MYB-Mediated Regulation of Anthocyanin Biosynthesis.International journal of molecular sciences · 2021
    Review
  11. Article
  12. Article
  13. Allelic Variation ofThe Plant cell · 2020
    Article
  14. Article
  15. Skin Color in Apple Fruit (Epigenomes · 2020
    Review
  16. Alternative Splicing in thePlant communications · 2020
    Article
  17. Perspectives of CRISPR/Cas-mediatedHorticulture research · 2020
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Cyril BrendoliseMt Albert Research Centre, Plant and Food Research, Auckland, New Zealand.
Richard V EspleyMt Albert Research Centre, Plant and Food Research, Auckland, New Zealand.
Kui Lin-WangMt Albert Research Centre, Plant and Food Research, Auckland, New Zealand.
William LaingFitzherbert Science Centre, Plant and Food Research, Palmerston North, New Zealand.
Yongyan PengMt Albert Research Centre, Plant and Food Research, Auckland, New Zealand.
Tony McGhieFitzherbert Science Centre, Plant and Food Research, Palmerston North, New Zealand.
Supinya DejnopratMt Albert Research Centre, Plant and Food Research, Auckland, New Zealand.
Sumathi TomesMt Albert Research Centre, Plant and Food Research, Auckland, New Zealand.
Roger P HellensCentre for Tropical Crops and Biocommodities, Queensland University of Technology, Brisbane, QLD, Australia.
Andrew C AllanMt Albert Research Centre, Plant and Food Research, Auckland, New Zealand.
Plant & Food Research · NZQueensland University of Technology · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In apple, the MYB transcription factor MYB10 controls the accumulation of anthocyanins. MYB10 is able to auto-activate its expression by binding its own promoter at a specific motif, the R1 motif. In some apple accessions a natural mutation, termed R6, has more copies of this motif within the MYB10 promoter resulting in stronger auto-activation and elevated anthocyanins. Here we show that other anthocyanin-related MYBs selected from apple, pear, strawberry, petunia, kiwifruit and Arabidopsis are able to activate promoters containing the R6 motif. To examine the specificity of this motif, members of the R2R3 MYB family were screened against a promoter harboring the R6 mutation. Only MYBs from subgroups 5 and 6 activate expression by binding the R6 motif, with these MYBs sharing conserved residues in their R2R3 DNA binding domains. Insertion of the apple R6 motif into orthologous promoters of

Indexed as

anthocyaninbiotechnologyflavonoidsMYBpromotertranscription factor

Identifiers

PMID29163590
PMCPMC5671642
OpenAlexW2765624594

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.