Evidence map›Paper›PMID 29163532›Full record

ArticleFrontiers in immunology2017

Biodistribution and Immunogenicity of Allogeneic Mesenchymal Stem Cells in a Rat Model of Intraarticular Chondrocyte Xenotransplantation.

Maribel Marquina, Javier A Collado, Magdiel Pérez-Cruz, Pablo Fernández-Pernas, Juan Fafián-Labora, Francisco J Blanco, Rafael Máñez, María C Arufe, Cristina Costa

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Maribel MarquinaInfectious Diseases and Transplantation Division, Institut d'Investigació Biomèdica de Bellvitge - IDIBELL, Bellvitge University Hospital, ICS, L'Hospitalet de Llobregat, Barcelona, Spain.
Javier A ColladoInfectious Diseases and Transplantation Division, Institut d'Investigació Biomèdica de Bellvitge - IDIBELL, Bellvitge University Hospital, ICS, L'Hospitalet de Llobregat, Barcelona, Spain.
Magdiel Pérez-CruzInfectious Diseases and Transplantation Division, Institut d'Investigació Biomèdica de Bellvitge - IDIBELL, Bellvitge University Hospital, ICS, L'Hospitalet de Llobregat, Barcelona, Spain.
Pablo Fernández-PernasCellular Therapy and Medicine Regenerative Group, Department of Medicine, Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas, Universidade da Coruña, As Xubias, A Coruña, Spain.
Juan Fafián-LaboraCellular Therapy and Medicine Regenerative Group, Department of Medicine, Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas, Universidade da Coruña, As Xubias, A Coruña, Spain.
Francisco J BlancoGrupo de Proteómica-ProteoRed/Plataforma PBR2-ISCIII, Servicio de Reumatología, Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas, Universidade da Coruña, As Xubias, A Coruña, Spain.
Rafael MáñezInfectious Diseases and Transplantation Division, Institut d'Investigació Biomèdica de Bellvitge - IDIBELL, Bellvitge University Hospital, ICS, L'Hospitalet de Llobregat, Barcelona, Spain.
María C ArufeCellular Therapy and Medicine Regenerative Group, Department of Medicine, Instituto de Investigación Biomédica de A Coruña (INIBIC), Complexo Hospitalario Universitario de A Coruña (CHUAC), Sergas, Universidade da Coruña, As Xubias, A Coruña, Spain.
Cristina CostaInfectious Diseases and Transplantation Division, Institut d'Investigació Biomèdica de Bellvitge - IDIBELL, Bellvitge University Hospital, ICS, L'Hospitalet de Llobregat, Barcelona, Spain.
Bellvitge University Hospital · ESComplexo Hospitalario Universitario A Coruña · ESUniversidade da Coruña · ESInstitut d'Investigació Biomédica de Bellvitge · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Xenogeneic chondrocytes and allogeneic mesenchymal stem cells (MSC) are considered a potential source of cells for articular cartilage repair. We here assessed the immune response triggered by xenogeneic chondrocytes when injected intraarticularly, as well as the immunoregulatory effect of allogeneic bone marrow-derived MSC after systemic administration. To this end, a discordant xenotransplantation model was established by injecting three million porcine articular chondrocytes (PAC) into the femorotibial joint of Lewis rats and monitoring the immune response. First, the fate of MSC injected using various routes was monitored in an

Indexed as

alloimmunitychondrocytesimmune rejectionmesenchymal stem cellsxenotransplantation

Identifiers

PMID29163532
PMCPMC5681521
OpenAlexW2766749964

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.