ArticleFrontiers in immunology2017
Repertoire of BALB/c Mice Natural Anti-Carbohydrate Antibodies: Mice vs. Humans Difference, and Otherness of Individual Animals.
Article in Frontiers in immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Standardized Photobiomodulation Dosimetry Targeting the Base of Calvarial Critical-Sized Defects for Bone Regeneration: A Preclinical RCT Comparing Flattop vs. Gaussian Beam Profiles, with or Without Bio-OssJournal of functional biomaterials · 2026Article
- O-glycosylation of IgA1 and the pathogenesis of an autoimmune disease IgA nephropathy.Glycobiology · 2024Review
- Serum antibody screening using glycan arrays.Chemical Society reviews · 2024Review
- Influence of microbiota-driven natural antibodies on dengue transmission.Frontiers in immunology · 2024Article
- Unique B-1 cells specific for both N-pyrrolated proteins and DNA evolve with apolipoprotein E deficiency.The Journal of biological chemistry · 2022Article
- Unique repertoire of anti-carbohydrate antibodies in individual human serum.Scientific reports · 2020Article
- Emergence and significance of carbohydrate-specific antibodies.Genes and immunity · 2020Review
- Glycan Reactive Natural Antibodies and Viral Immunity.Viral immunology · 2020Review
- Development of smart anti-glycan reagents using immunized lampreys.Communications biology · 2020Article
- Highly modified and immunoactive N-glycans of the canine heartworm.Nature communications · 2019Article
- The Formation of Glycan-Specific Natural Antibodies Repertoire in GalT-KO Mice Is Determined by Gut Microbiota.Frontiers in immunology · 2019Article
- Evaluation of anti α-d-GlcRSC advances · 2018Article
- Repertoire of Abs primed by bacteria in gnotobiotic mice.Innate immunity · 2018Article
- Repertoire of BALB/c Mice Natural Anti-Carbohydrate Antibodies: Mice vs. Humans Difference, and Otherness of Individual Animals.Frontiers in immunology · 2017Article
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Authors and funding
5 authors.
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Abstract
One of the most common genetic backgrounds for mice used as a model to investigate human diseases is the inbred BALB/c strain. This work is aimed to characterize the pattern of natural anti-carbohydrate antibodies present in the serum of 20 BALB/c mice by printed glycan array technology and to compare their binding specificities with that of human natural anti-carbohydrate antibodies. Natural antibodies (NAbs) from the serum of BALB/c mice interacted with 71 glycans from a library of 419 different carbohydrate structures. However, only seven of these glycans were recognized by the serum of all the animals studied, and other five glycans by at least 80% of mice. The pattern of the 12 glycans mostly recognized by the circulating antibodies of BALB/c mice differed significantly from that observed with natural anti-carbohydrate antibodies in humans. This lack of identical repertoires of natural anti-carbohydrate antibodies between individual inbred mice, and between mice and humans, should be taken into consideration when mouse models are intended to be used for investigation of NAbs in biomedical research.
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