ArticleFrontiers in immunology2017
Prophenoloxidase-Mediated
Article in Frontiers in immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 49 citations in OpenAlex.
- N-Acetylcysteine Attacks Phenoloxidase to Inhibit Insect Melanization and Boost Fungal Virulence.Journal of fungi (Basel, Switzerland) · 2026Article
- Article
- Larvicidal and Immunomodulatory Effects of Conidia and Blastospores ofJournal of fungi (Basel, Switzerland) · 2025Article
- Innate Immunity in Insects: The Lights and Shadows of Phenoloxidase System Activation.International journal of molecular sciences · 2025Review
- Article
- Prophenoloxidase ofInternational journal of molecular sciences · 2022Article
- Galleria mellonella immune melanization is fungicidal during infection.Communications biology · 2022Article
- Biological Activity of ExtractArchives of Razi Institute · 2022Article
- Serpin-4 Facilitates Baculovirus Infection by Inhibiting Melanization in Asian Corn Borer,Frontiers in immunology · 2022Article
- Distinct Responses ofJournal of immunology (Baltimore, Md. : 1950) · 2021Article
- Involvement of Epidermis Cell Proliferation in Defense AgainstFrontiers in immunology · 2021Article
- A M35 family metalloprotease is required for fungal virulence against insects by inactivating host prophenoloxidases and beyond.Virulence · 2020Article
- Schizophyllum commune induced oxidative stress and immunosuppressive activity in Spodoptera litura.BMC microbiology · 2020Article
- Integrated Management ofJournal of fungi (Basel, Switzerland) · 2020Article
- Review
- Unveiling the function and regulation control of the DUF3129 family proteins in fungal infection of hosts.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Article
- Penaeid shrimp genome provides insights into benthic adaptation and frequent molting.Nature communications · 2019Article
- Insect anal droplets contain diverse proteins related to gut homeostasis.BMC genomics · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Skin immunity protects animals from airborne pathogen infection. Unlike mammals, arthropods, including insects, undergo periodic ecdysis to grow and develop. Newly molted insects emerge with unsclerotized thin cuticles but successfully escape pathogenic infections during the post-molt period. Here we show that prophenoloxidases (PPOs) in molting fluids remain bioactive on the integument and impede fungal infection after ecdysis. We found that the purified plasma PPOs or recombinant PPOs could effectively bind to fungal spores (conidia) by targeting the cell wall components chitin and β-1,3-glucan. Pretreatment of the spores of the fungal pathogen
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.