Evidence map›Paper›PMID 29163509›Full record

ArticleFrontiers in immunology2017

Downregulated IL-21 Response and T Follicular Helper Cell Exhaustion Correlate with Compromised CD8 T Cell Immunity during Chronic Toxoplasmosis.

Magali M Moretto, SuJin Hwang, Imtiaz A Khan

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.4field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 30 citations in OpenAlex.

  1. Protective function and differentiation cues of brain-resident CD8+ T cells during surveillance of latentProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  2. Article
  3. Article
  4. Article
  5. CD39Oncoimmunology · 2023
    Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Accelerator or Brake: Immune Regulators in Malaria.Frontiers in cellular and infection microbiology · 2020
    Review
  11. Article
  12. T cell-mediated immunity to malaria.Nature reviews. Immunology · 2019
    Review
  13. Toxoplasma: Immunity and Pathogenesis.Current clinical microbiology reports · 2019
    Article
  14. Review
  15. Review
  16. Interleukin (IL)-21 in Inflammation and Immunity During Parasitic Diseases.Frontiers in cellular and infection microbiology · 2019
    Review
  17. Frontiers in cellular and infection microbiology · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Magali M MorettoDepartment Microbiology, Immunology and Tropical Medicine, The George Washington University, Washington, DC, United States.
SuJin HwangDepartment Microbiology, Immunology and Tropical Medicine, The George Washington University, Washington, DC, United States.
Imtiaz A KhanDepartment Microbiology, Immunology and Tropical Medicine, The George Washington University, Washington, DC, United States.
George Washington University · US

Funding

LONG TERM IMMUNITY AGAINST TOXOPLASMOSISR01AI033325 · NIAID · LOUISIANA STATE UNIV HSC NEW ORLEANS · PI KHAN, IMTIAZ AHMED · 1998 to 2020
$6.2M
NIAID NIH HHS R01 AI033325
6 · The paper itself

Abstract

CD8 T cells are important for maintaining the chronicity of

Indexed as

exhaustionIL-21latent infectionmemory CD8 T cellsT follicular helper cellsToxoplasma gondii

Identifiers

PMID29163509
PMCPMC5671557
OpenAlexW2766619173

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.