Evidence map›Paper›PMID 29163504›Full record

ArticleFrontiers in immunology2017

Butyrate Conditions Human Dendritic Cells to Prime Type 1 Regulatory T Cells

Maria M M Kaisar, Leonard R Pelgrom, Alwin J van der Ham, Maria Yazdanbakhsh, Bart Everts

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 155 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
155citing papers in PubMed, 2 pooled it
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

155 citing papers in PubMed, 2 syntheses or guidelines pooled it, 209 citations in OpenAlex.

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  10. Short-chain fatty acids.Nature metabolism · 2026
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95 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Maria M M KaisarDepartment of Parasitology, Leiden University Medical Center (LUMC), Leiden, Netherlands.
Leonard R PelgromDepartment of Parasitology, Leiden University Medical Center (LUMC), Leiden, Netherlands.
Alwin J van der HamDepartment of Parasitology, Leiden University Medical Center (LUMC), Leiden, Netherlands.
Maria YazdanbakhshDepartment of Parasitology, Leiden University Medical Center (LUMC), Leiden, Netherlands.
Bart EvertsDepartment of Parasitology, Leiden University Medical Center (LUMC), Leiden, Netherlands.
Leiden University Medical Center · NLUniversity of Indonesia · ID

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recently, it has become clear that short-chain fatty acids (SCFAs), and in particular butyrate, have anti-inflammatory properties. Murine studies have shown that butyrate can promote regulatory T cells

Indexed as

butyratedendritic cellsG-coupled protein receptor 109Ahistone deacetylasesretinaldehyde dehydrogenaseretinoic acidshort-chain fatty acidstype 1 regulatory T cells

Identifiers

PMID29163504
PMCPMC5670331
OpenAlexW2765924996

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.