ArticleFrontiers in immunology2017
T-Cell Composition of the Lymph Node Is Associated with the Risk for Early Rejection after Renal Transplantation.
Article in Frontiers in immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Short-term prognosis of recipients with pretransplant exposure to immune checkpoint inhibitors after liver transplantation for hepatocellular carcinoma: A retrospective cohort study.Liver research (Beijing, China) · 2025Article
- Temporal and spatial dynamics of immune cells in spontaneous liver transplant tolerance.iScience · 2023Article
- Effect of panel reactive antibodies on T cell immunity reinstatement following renal transplantation.World journal of transplantation · 2022Article
- Neoadjuvant Programmed Cell Death 1 (PD-1) Inhibitor Treatment in Patients With Hepatocellular Carcinoma Before Liver Transplant: A Cohort Study and Literature Review.Frontiers in immunology · 2021Review
- A very low thymus function identifies patients with substantial increased risk for long-term mortality after kidney transplantation.Immunity & ageing : I & A · 2020Article
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8 authors.
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Abstract
backgroundThe T-cell composition within the lymph node (LN) of end-stage renal disease (ESRD) patients differs from the composition within the circulation. Activation of the alloreactive T-cell response within secondary lymphoid organs is important after organ transplantation. However, to date no data are present on LN T-cell subsets and the risk for acute rejection after kidney transplantation.
methodsT cells from LNs of ESRD patients were analyzed for frequency of recent thymic emigrants, relative telomere length, expression of differentiation markers, and were related to the development of early acute rejection (EAR), occurring within 3 months after renal transplantation (RT). Furthermore, the alloreactive potential of mononuclear cells isolated from the LN and peripheral blood of 10 patients was analyzed. Measures of alloreactive potential included proliferation, cytokine production, frequencies of interferon-gamma-producing cells, and the presence of cytotoxic molecules.
resultsPatients with EAR were younger (
conclusionA lower CD4:CD8 ratio in the LN is associated with a higher risk for the development of rejection within 3 months after RT.
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