ArticleFrontiers in immunology2017
Treadmill Slope Modulates Inflammation, Fiber Type Composition, Androgen, and Glucocorticoid Receptors in the Skeletal Muscle of Overtrained Mice.
Article in Frontiers in immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Epigenetic Modifications as Outcomes of Exercise Interventions Related to Specific Metabolic Alterations: A Systematic Review.Lifestyle genomics · 2019Pooled it
- MAPK, androgen, and glucocorticoid receptor phosphorylation following high-frequency resistance exercise non-functional overreaching.European journal of applied physiology · 2019Trial
- The Effect of an Essential Amino Acid Supplement on Muscle Performance and Inflammation in an Animal Model of Overtraining.Nutrients · 2026Article
- The effect of nandrolone decanoate administration on fatigue during a volume-overload stress in male mice.Physiological reports · 2025Article
- Intranasal methylene blue administration confers neuroprotection in rats subjected to exhaustive exercise training.Frontiers in behavioral neuroscience · 2025Article
- Establishment of a Neurodegenerative Charcot Mouse Model.Foot & ankle international · 2023Article
- Cytokines as Biomarkers for Evaluating Physical Exercise in Trained and Non-Trained Individuals: A Narrative Review.International journal of molecular sciences · 2023Review
- Myocytic androgen receptor overexpression does not affect sex differences in adaptation to chronic endurance exercise.Biology of sex differences · 2022Article
- Excessive Treadmill Training Produces different Cardiac-related MicroRNA Profiles in the Left and Right Ventricles in Mice.International journal of sports medicine · 2022Article
- Applications of Eccentric Exercise to Improve Muscle and Mobility Function in Older Adults.Annals of geriatric medicine and research · 2022Article
- The effect of exercise on cytokines: implications for musculoskeletal health: a narrative review.BMC sports science, medicine & rehabilitation · 2022Review
- Androgen receptor regulates the proliferation of myoblasts under appropriate or excessive stretch through IGF-1 receptor mediated p38 and ERK1/2 pathways.Nutrition & metabolism · 2021Article
- Article
- Impact of Different Physical Exercises on the Expression of Autophagy Markers in Mice.International journal of molecular sciences · 2021Article
- Moderate, but Not Excessive, Training Attenuates Autophagy Machinery in Metabolic Tissues.International journal of molecular sciences · 2020Article
- Pathophysiology of exercise-induced muscle damage and its structural, functional, metabolic, and clinical consequences.Physiological research · 2020Review
- The Molecular Adaptive Responses of Skeletal Muscle to High-Intensity Exercise/Training and Hypoxia.Antioxidants (Basel, Switzerland) · 2020Review
- Excessive Treadmill Training Enhances Brain-Specific MicroRNA-34a in the Mouse Hippocampus.Frontiers in molecular neuroscience · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Overtraining (OT) may be defined as an imbalance between excessive training and adequate recovery period. Recently, a downhill running-based overtraining (OTR/down) protocol induced the nonfunctional overreaching state, which is defined as a performance decrement that may be associated with psychological and hormonal disruptions and promoted intramuscular and systemic inflammation. To discriminate the eccentric contraction effects on interleukin 1beta (IL-1β), IL-6, IL-10, IL-15, and SOCS-3, we compared the release of these cytokines in OTR/down with other two OT protocols with the same external load (i.e., the product between training intensity and volume), but performed in uphill (OTR/up) and without inclination (OTR). Also, we evaluated the effects of these OT models on the muscle morphology and fiber type composition, serum levels of fatigue markers and corticosterone, as well as androgen receptor (AR) and glucocorticoid receptor (GR) expressions. For extensor digitorum longus (EDL), OTR/down and OTR groups increased the cytokines and exhibited micro-injuries with polymorphonuclear infiltration. While OTR/down group increased the cytokines in soleus muscle, OTR/up group only increased IL-6. All OT groups presented micro-injuries with polymorphonuclear infiltration. In serum, while OTR/down and OTR/up protocols increased IL-1β, IL-6, and tumor necrosis factor alpha, OTR group increased IL-1β, IL-6, IL-15, and corticosterone. The type II fibers in EDL and soleus, total and phosphorylated AR levels in soleus, and total GR levels in EDL and soleus were differentially modulated by the OT protocols. In summary, the proinflammatory cytokines were more sensitive for OTR/down than for OTR/up and OTR. Also, the specific treadmill inclination of each OT model influenced most of the other evaluated parameters.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.