ArticleFrontiers in immunology2017
Cigarette Smoking Triggers Colitis by IFN-γ
Article in Frontiers in immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Modifiable lifestyle and metabolic risk factors for colorectal polyps: a systematic review and meta-analysis.Frontiers in public health · 2025Pooled it
- Comparison of Azathioprine-Induced Pancreatitis and Gastrointestinal Intolerance in IBD: Role of Demographics, Clinical Variables, and HLA DQA1/DRB1 Alleles.Journal of clinical medicine · 2025Article
- Predictors of Incident Serrated Polyps: Results from a Large Multicenter Clinical Trial.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2022Article
- Exploring the Inflammatory Pathogenesis of Colorectal Cancer.Diseases (Basel, Switzerland) · 2021Review
- Impact of Cigarette Smoking on the Risk of Osteoporosis in Inflammatory Bowel Diseases.Journal of clinical medicine · 2021Review
- The impact of tobacco smoking on treatment choice and efficacy in inflammatory bowel disease.Intestinal research · 2021Review
- Enhanced lung inflammatory response in whole-body compared to nose-only cigarette smoke-exposed mice.Respiratory research · 2021Article
- The effects of cigarettes and alcohol on intestinal microbiota in healthy men.Journal of microbiology (Seoul, Korea) · 2020Article
- Determination of the molecular mechanism by which macrophages and γδ-T cells contribute to ZOL-induced ONJ.Aging · 2020Article
- Intratracheal Ovalbumin Administration Induces Colitis Through the IFN-γ Pathway in Mice.Frontiers in immunology · 2019Article
- Cigarette smoke extract acts directly on CD4 T cells to enhance Th1 polarization and reduce memory potential.Cellular immunology · 2018Article
- Impact of Cigarette Smoking on the Gastrointestinal Tract Inflammation: Opposing Effects in Crohn's Disease and Ulcerative Colitis.Frontiers in immunology · 2018Review
- Macrophage Depletion Protects against Cigarette Smoke-Induced Inflammatory Response in the Mouse Colon and Lung.Frontiers in physiology · 2018Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The increased incidence of Crohn's disease in smokers has been recently reported, suggesting a strong association of cigarette smoke (CS) with colitis. However, the mechanism of the action of CS on colitis has not yet been explored. Here, we demonstrate that CS exposure is sufficient to induce colitis in mice. Interestingly, the colitis is mainly mediated by Th1, but not Th17, responses. CD4
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.