ArticleFrontiers in microbiology2017
Relationship between Gingival Crevicular Fluid Microbiota and Cytokine Profile in Periodontal Host Homeostasis.
Article in Frontiers in microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 37 citations in OpenAlex.
- The Impact of Cytokines Expression in Peri-implant Crevicular Fluid Associated with Keratinized Tissue Augmentation via Xenogeneic Collagen Matrix: A Pilot Study.European journal of dentistry · 2026Article
- Effects of initial periodontal treatment on heat shock protein 90 and Interleukin-1β levels in gingival crevicular fluid of stage III periodontitis patients.BMC oral health · 2025Article
- Deep metaproteomic mapping of gingival crevicular fluid reveals distinct microbial community at prepubertal and circumpubertal stages.BMC oral health · 2025Article
- Gingival Crevicular Fluid Biomarkers During Periodontitis Progression and After Periodontal Treatment.Journal of clinical periodontology · 2025Article
- Article
- Cytokine expression in gingival crevicular fluid around teeth opposing dental implants and 3-unit fixed partial dentures in a cross-sectional study.Head & face medicine · 2023Article
- Analysis of Salivary Levels of IL-1β, IL17A, OPG and RANK-L in Periodontitis Using the 2017 Classification of Periodontal Diseases-An Exploratory Observational Study.Journal of clinical medicine · 2023Article
- Associations between inflammation-related LL-37 with subgingival microbial dysbiosis in rheumatoid arthritis patients.Clinical oral investigations · 2022Article
- Subgingival Microbiota and Cytokines Profile Changes in Patients with Periodontitis: A Pilot Study Comparing Healthy and Diseased Sites in the Same Oral Cavities.Microorganisms · 2021Article
- Gingival Crevicular Fluid (GCF): A Diagnostic Tool for the Detection of Periodontal Health and Diseases.Molecules (Basel, Switzerland) · 2021Review
- Oral Dysbiosis in Severe Forms of Periodontitis Is Associated With Gut Dysbiosis and Correlated With Salivary Inflammatory Mediators: A Preliminary Study.Frontiers in oral health · 2021Article
- Dysbiosis From a Microbial and Host Perspective Relative to Oral Health and Disease.Frontiers in microbiology · 2021Review
- The "Gum-Gut" Axis in Inflammatory Bowel Diseases: A Hypothesis-Driven Review of Associations and Advances.Frontiers in immunology · 2021Review
- Deep metagenomics examines the oral microbiome during dental caries, revealing novel taxa and co-occurrences with host molecules.Genome research · 2021Article
- Gingival Crevicular Fluid Cytokines in Moderate and Deep Sites of Stage III Periodontitis Patients in Different Rates of Clinical Progression.Biomedicines · 2020Article
- Diagnostic Models for Screening of Periodontitis with Inflammatory Mediators and Microbial Profiles in Saliva.Diagnostics (Basel, Switzerland) · 2020Article
- Identification of Salivary Microbiota and Its Association With Host Inflammatory Mediators in Periodontitis.Frontiers in cellular and infection microbiology · 2019Article
- Cytokine Thresholds in Gingival Crevicular Fluid with Potential Diagnosis of Chronic Periodontitis Differentiating by Smoking Status.Scientific reports · 2018Article
- Evaluating the effectiveness of clarithromycin as an adjunct to scaling and root planing: A randomized clinical trial.Journal of Indian Society of PeriodontologyArticle
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As potential biomarkers in periodontitis, microbiome, and cytokines have recently been extensively investigated, but combined analyses of the variations between the microbial structure and cytokine composition are rare. The present study aimed to investigate whether there are differences in the combined profile of microbiome and cytokines in individuals with or without periodontitis. The microbiome and cytokine composition in gingival crevicular fluid (GCF) from 16 patients and 15 controls from Jishi Shan (Gansu, China) were analyzed using 454 pyrosequencing and RayBio Quantibody Arrays. The results showed that a higher co-occurrence of genera in periodontitis group compared with the healthy group, as evaluated by Schoener's abundance-based co-occurrence index. C-reactive protein (CRP) was significantly (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.