ArticleFrontiers in neurology2017
Parkinson's Disease Severity at 3 Years Can Be Predicted from Non-Motor Symptoms at Baseline.
Article in Frontiers in neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Rate of motor progression in Parkinson's disease: a systematic review and meta-analysis.Frontiers in neurology · 2024Pooled it
- LRRK2 p.G2385R and p.R1628P variants in a multi-ethnic Asian Parkinson's Cohort: epidemiology and clinical insights.NPJ Parkinson's disease · 2025Article
- Clinical Impression of Severity Index for Parkinson's Disease and Its Association to Health-Related Quality of Life.Movement disorders clinical practice · 2023Article
- SIALORRHEA AND XEROSTOMIA IN PARKINSON'S DISEASE PATIENTS.Acta clinica Croatica · 2022Review
- Low skull bone density is associated with poor motor prognosis in women with Parkinson's disease.Frontiers in aging neuroscience · 2022Article
- Baseline predictors of progression of Parkinson's disease in a sample of Egyptian patients: clinical and biochemical.The Egyptian journal of neurology, psychiatry and neurosurgery · 2022Article
- Impact of Isolation During the COVID-19 Pandemic on the Patient Burden of Parkinson's Disease: A PMD Alliance Survey.Neuropsychiatric disease and treatment · 2022Article
- Evolution of Quality of Life in Persons with Parkinson's Disease: A Prospective Cohort Study.Journal of clinical medicine · 2021Article
- Alpha-Synuclein as a Biomarker of Parkinson's Disease: Good, but Not Good Enough.Frontiers in aging neuroscience · 2021Review
- Sicca Symptoms in Parkinson's Disease: Association with Other Nonmotor Symptoms and Health-Related Quality of Life.Parkinson's disease · 2020Article
- Synaptic plasticity and levodopa-induced dyskinesia: electrophysiological and structural abnormalities.Journal of neural transmission (Vienna, Austria : 1996) · 2018Review
- Epidemiology of autonomic dysfunction in Parkinson's disease (Review).Medicine internationalReview
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aim of this study is to present a predictive model of Parkinson's disease (PD) global severity, measured with the Clinical Impression of Severity Index for Parkinson's Disease (CISI-PD).
methodsThis is an observational, longitudinal study with annual follow-up assessments over 3 years (four time points). A multilevel analysis and multiple imputation techniques were performed to generate a predictive model that estimates changes in the CISI-PD at 1, 2, and 3 years.
resultsThe clinical state of patients (CISI-PD) significantly worsened in the 3-year follow-up. However, this change was of small magnitude (effect size: 0.44). The following baseline variables were significant predictors of the global severity change: baseline global severity of disease, levodopa equivalent dose, depression and anxiety symptoms, autonomic dysfunction, and cognitive state. The goodness-of-fit of the model was adequate, and the sensitive analysis showed that the data imputation method applied was suitable.
conclusionDisease progression depends more on the individual's baseline characteristics than on the 3-year time period. Results may contribute to a better understanding of the evolution of PD including the non-motor manifestations of the disease.
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