ArticleFrontiers in human neuroscience2017
Tai Chi Chuan and Baduanjin Mind-Body Training Changes Resting-State Low-Frequency Fluctuations in the Frontal Lobe of Older Adults: A Resting-State fMRI Study.
Article in Frontiers in human neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 8 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
52 citing papers in PubMed, 8 syntheses or guidelines pooled it, 76 citations in OpenAlex.
- Tai Chi, brain activity and psychological outcomes: a systematic scoping review.Frontiers in psychology · 2026Pooled it
- The effectiveness of Tai Chi for patients with mild cognitive impairment: a systematic review and meta-analysis.Frontiers in neuroscience · 2024Pooled it
- The neurobiological effects of mind-body exercise: a systematic review and meta-analysis of neuroimaging studies.Scientific reports · 2023Pooled it
- The Comparative Effectiveness of Traditional Chinese Medicine Exercise Therapies in Elderly People With Mild Cognitive Impairment: A Systematic Review and Network Meta-Analysis.Frontiers in neurology · 2022Pooled it
- Baduanjin exercise: A potential promising therapy toward osteoporosis.Frontiers in medicine · 2022Pooled it
- Chronic effects of different exercise types on brain activity in healthy older adults and those with Parkinson's disease: A systematic review.Frontiers in physiology · 2022Pooled it
- The effect of mind-body exercise on memory in older adults: a systematic review and meta-analysis.Aging clinical and experimental research · 2021Pooled it
- Effects of Tai Chi on Patients with Mild Cognitive Impairment: A Systematic Review and Meta-analysis of Randomized Controlled Trials.BioMed research international · 2021Pooled it
- Evaluation of Mindfulness Training Combined with Aerobic Exercise on Neurological Function and Quality of Life in Patients with Peripheral Neuropathy Type 2 Diabetes Mellitus.Contrast media & molecular imaging · 2022Trial
- Tai chi improves psychoemotional state, cognition, and motor learning in older adults during the COVID-19 pandemic.Experimental gerontology · 2021Trial
- Mind-body exercise improves cognitive function and modulates the function and structure of the hippocampus and anterior cingulate cortex in patients with mild cognitive impairment.NeuroImage. Clinical · 2019Trial
- Brain resting state functional connectivity changes with aerobic exercise, and mindfulness: A narrative review.Sports medicine and health science · 2026Review
- Neuroimaging insights from Wistar-Kyoto rats under chronic mild stress: morphological and metabolic brain correlates of treatment-resistant depression.Scientific reports · 2026Article
- Global research trends and hotspots in the health effects of Tai Chi on older adults: a bibliometric analysis (2010-2025).Frontiers in public health · 2026Article
- Effects of tai chi on balance function among stroke patients: a meta-analysis.Archives of medical science : AMS · 2026Review
- Effects of Tai Chi on fatigue and resting-state brain activity in chronic fatigue syndrome: a randomized controlled fMRI study.Frontiers in neuroscience · 2026Article
- Tai chi or cognitive behavioural therapy for treating insomnia in middle aged and older adults: randomised non-inferiority trial.BMJ (Clinical research ed.) · 2025Article
- Efficacy of Baduanjin Versus Brisk Walking on Cognitive and Physical Functions in Schizophrenia: A Three-Arm Randomized Controlled Trial.Healthcare (Basel, Switzerland) · 2025Article
- The Science of Tai Chi andJournal of integrative and complementary medicine · 2025Review
- Article
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 2 countries.
Funding
Abstract
Age-related cognitive decline is a significant public health concern. Recently, non-pharmacological methods, such as physical activity and mental training practices, have emerged as promising low-cost methods to slow the progression of age-related memory decline. In this study, we investigated if Tai Chi Chuan (TCC) and Baduanjin modulated the fractional amplitude of low-frequency fluctuations (fALFF) in different frequency bands (low-frequency: 0.01-0.08 Hz; slow-5: 0.01-0.027 Hz; slow-4: 0.027-0.073 Hz) and improved memory function. Older adults were recruited for the randomized study. Participants in the TCC and Baduanjin groups received 12 weeks of training (1 h/day for 5 days/week). Participants in the control group received basic health education. Each subject participated in memory tests and fMRI scans at the beginning and end of the experiment. We found that compared to the control group: (1) TCC and Baduanjin groups demonstrated significant improvements in memory function; (2) TCC increased fALFF in the dorsolateral prefrontal cortex (DLPFC) in the slow-5 and low-frequency bands; and (3) Baduanjin increased fALFF in the medial PFC in the slow-5 and low-frequency bands. This increase was positively associated with memory function improvement in the slow-5 and low-frequency bands across the TCC and Baduanjin groups. Our results suggest that TCC and Baduanjin may work through different brain mechanisms to prevent memory decline due to aging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.