ReviewFrontiers in systems neuroscience2017
Disentangling the Role of the MEC and LEC in the Processing of Spatial and Non-Spatial Information: Contribution of Lesion Studies.
Review in Frontiers in systems neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 58 citations in OpenAlex.
- Coordinating Cognition: The Entorhinal Cortex in Mnemonic, Temporal and Spatial Representation.Cells · 2026Review
- Lateral entorhinal cortex supports behaviorally-induced hippocampal ensemble stability for reliable memory recall.bioRxiv : the preprint server for biology · 2026Article
- Temporal Coding rather than Circuit Wiring allows Hippocampal CA3 Neurons to Dynamically Distinguish Different Cortical Inputs.bioRxiv : the preprint server for biology · 2026Article
- Heterogeneity of astrocyte density, morphology and connexins in the mouse hippocampus.Frontiers in neuroanatomy · 2026Article
- Continuous attractor dynamics in spatial navigation: from population geometry to flexible computation.Frontiers in neuroscience · 2026Review
- Engram cell vulnerability in neurodegeneration: from mechanistic insights to therapeutic horizons.Frontiers in aging neuroscience · 2026Review
- Medial entorhinal VIP-expressing interneurons receive input from the thalamic anterior dorsal nucleus and are critical for spatial memory.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- AAV9-mediated transduction of memory circuits following convection-enhanced delivery into the olfactory bulbs.Gene therapy · 2025Article
- A central role for acetylcholine in entorhinal cortex function and dysfunction with age in humans and mice.Cell reports · 2025Article
- Neural circuits for goal-directed navigation across species.Trends in neurosciences · 2024Review
- Constitutive knockout of interleukin-6 ameliorates memory deficits and entorhinal astrocytosis in the MRL/lpr mouse model of neuropsychiatric lupus.Journal of neuroinflammation · 2024Article
- A consistent map in the medial entorhinal cortex supports spatial memory.Nature communications · 2024Article
- Impairment of entorhinal cortex network activity in Alzheimer's disease.Frontiers in aging neuroscience · 2024Review
- Direct cortical inputs to hippocampal area CA1 transmit complementary signals for goal-directed navigation.Neuron · 2023Article
- A consistent map in the medial entorhinal cortex supports spatial memory.bioRxiv : the preprint server for biology · 2023Article
- The medial entorhinal cortex is necessary for the stimulus control over hippocampal place fields by distal, but not proximal, landmarks.Hippocampus · 2023Article
- Different Types of Survey-Based Environmental Representations: Egocentric vs. Allocentric Cognitive Maps.Brain sciences · 2023Article
- Lateral entorhinal cortex inputs modulate hippocampal dendritic excitability by recruiting a local disinhibitory microcircuit.Cell reports · 2023Article
- Behavioral pattern separation and cognitive flexibility are enhanced in a mouse model of increased lateral entorhinal cortex-dentate gyrus circuit activity.Frontiers in behavioral neuroscience · 2023Article
- Medial Temporal Lobe Tau Aggregation Relates to Divergent Cognitive and Emotional Empathy Abilities in Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2023Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is now widely accepted that the entorhinal cortex (EC) plays a pivotal role in the processing of spatial information and episodic memory. The EC is segregated into two sub-regions, the medial EC (MEC) and the lateral EC (LEC) but a comprehensive understanding of their roles across multiple behavioral contexts remains unclear. Considering that it is still useful to investigate the impact of lesions of EC on behavior, we review the contribution of lesion approach to our knowledge of EC functions. We show that the MEC and LEC play different roles in the processing of spatial and non-spatial information. The MEC is necessary to the use of distal but not proximal landmarks during navigation and is crucial for path integration, in particular integration of linear movements. Consistent with predominant hypothesis, the LEC is important for combining the spatial and non-spatial aspects of the environment. However, object exploration studies suggest that the functional segregation between the MEC and the LEC is not as clearly delineated and is dependent on environmental and behavioral factors. Manipulation of environmental complexity and therefore of cognitive demand shows that the MEC and the LEC are not strictly necessary to the processing of spatial and non-spatial information. In addition we suggest that the involvement of these sub-regions can depend on the kind of behavior, i.e., navigation or exploration, exhibited by the animals. Thus, the MEC and the LEC work in a flexible manner to integrate the "what" and "where" information in episodic memory upstream the hippocampus.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.