ReviewFrontiers in systems neuroscience2017
Pauses in Striatal Cholinergic Interneurons: What is Revealed by Their Common Themes and Variations?
Review in Frontiers in systems neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- The GPCR Smoothened on cholinergic interneurons modulates dopamine-associated acetylcholine dynamics, learning, and effort management.iScience · 2026Article
- Dopamine 2 receptor ablation from cholinergic neurons attenuates L-DOPA induced dyskinesias.Frontiers in aging neuroscience · 2026Article
- Cholinergic modulation enables scalable action selection learning in a computational model of the striatum.Scientific reports · 2025Article
- Article
- Editorial: Mechanisms of cholinergic transmission in motivation and cognition.Frontiers in molecular neuroscience · 2025Article
- Extrinsic and intrinsic control of striatal cholinergic interneuron activity.Frontiers in molecular neuroscience · 2025Review
- Dynamic responses of striatal cholinergic interneurons control behavioral flexibility.Science advances · 2024Article
- G protein-coupled receptor modulation of striatal dopamine transmission: Implications for psychoactive drug effects.British journal of pharmacology · 2024Review
- Light-Controlled Electric Stimulation with Organic Electrolytic Photocapacitors Achieves Complex Neuronal Network Activation: Semi-Chronic Study in Cortical Cell Culture and Rat Model.Advanced healthcare materials · 2024Article
- A TAN-dopamine interaction mechanism based computational model of basal ganglia in action selection.Cognitive neurodynamics · 2024Article
- Corticotropin releasing factor alters the functional diversity of accumbal cholinergic interneurons.Journal of neurophysiology · 2024Article
- The Integration of Top-down and Bottom-up Inputs to the Striatal Cholinergic Interneurons.Current neuropharmacology · 2024Article
- Developmental regulation of thalamus-driven pauses in striatal cholinergic interneurons.iScience · 2022Article
- Article
- Hippocampal-evoked inhibition of cholinergic interneurons in the nucleus accumbens.Cell reports · 2022Article
- Dopamine D2 receptors modulate the cholinergic pause and inhibitory learning.Molecular psychiatry · 2022Article
- Striatal Cholinergic Signaling in Time and Space.Molecules (Basel, Switzerland) · 2022Review
- Loss of GABA co-transmission from cholinergic neurons impairs behaviors related to hippocampal, striatal, and medial prefrontal cortex functions.Frontiers in behavioral neuroscience · 2022Article
- Ventral tegmental area GABAergic inhibition of cholinergic interneurons in the ventral nucleus accumbens shell promotes reward reinforcement.Nature neuroscience · 2021Article
- A spotlight on the elusive striatal cholinergic interneuron.Science (New York, N.Y.) · 2021Article
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Authors and funding
2 authors.
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Abstract
Striatal cholinergic interneurons, the so-called tonically active neurons (TANs), pause their firing in response to sensory cues and rewards during classical conditioning and instrumental tasks. The respective pause responses observed can demonstrate many commonalities, such as constant latency and duration, synchronous occurrence in a population of cells, and coincidence with phasic activities of midbrain dopamine neurons (DANs) that signal reward predictions and errors. Pauses can however also show divergent properties. Pause latencies and durations can differ in a given TAN between appetitive vs. aversive outcomes in classical conditioning, initial excitation can be present or absent, and a second pause can variably follow a rebound. Despite more than 20 years of study, the functions of these pause responses are still elusive. Our understanding of pause function is hindered by an incomplete understanding of how pauses are generated. In this mini-review article, we compare pause types, as well as current key hypotheses for inputs underlying pauses that include dopamine-induced inhibition through D
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