ReviewNature reviews. Gastroenterology & hepatology2018
Hepatitis E virus: advances and challenges.
Review in Nature reviews. Gastroenterology & hepatology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 186 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
186 citing papers in PubMed, 3 syntheses or guidelines pooled it, 347 citations in OpenAlex.
- The burden of HEV-related acute liver failure in Bangladesh, China and India: a systematic review and meta-analysis.BMC public health · 2023Pooled it
- Hepatitis E Virus in the Iberian Peninsula: A Systematic Review.Food and environmental virology · 2023Pooled it
- Epidemiology of hepatitis E virus infection in animals in Africa: a systematic review and meta-analysis.BMC veterinary research · 2021Pooled it
- Extrahepatic Replication and Genomic Signatures of the Hepatitis E Virus in the Kidney.Liver international : official journal of the International Association for the Study of the Liver · 2025Trial
- Identification of Host Interaction Partners of the Hepatitis E Virus Internal Ribosome Entry Site-Like RNA Using RNA-Protein Interaction Detection Assay and Yeast Three-Hybrid Assay.Methods in molecular biology (Clifton, N.J.) · 2027Article
- Viral entry defines the hepatitis E virus species barrier in murine hepatocytes.Emerging microbes & infections · 2026Article
- Hepatitis E Virus Infection in Pregnant Women.Microorganisms · 2026Review
- Transferrin receptor 1 is required for efficient hepatitis E virus production.PLoS pathogens · 2026Article
- Detection of Infectious Hepatitis E Virus in Retail Pork Pâté After Optimization of Extraction Protocols.Viruses · 2026Article
- Fatty acid regulation and phosphatidylethanolamine biosynthesis are important for hepatitis E virus replication.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Nationwide Detection and Molecular Characterization of Hepatitis E Virus RNA in Retail Pork Meat in Japan.Viruses · 2026Article
- Assessment of Population Immunity to Enteric Hepatitis Viruses in the Population of Belgrade.Epidemiologia (Basel, Switzerland) · 2026Article
- Rocahepevirus ratti: molecular evolution, zoonotic potential and public health impact.Nature communications · 2026Review
- Sexual transmission of hepatitis E virus via vaginal and rectal routes in a rabbit model.The Journal of general virology · 2026Article
- Quantitative Risk Assessment of Hepatitis E Virus from Shellfish Consumption Among Chinese Residents Using Monte Carlo Simulation.Microorganisms · 2026Article
- Viral hepatitis after liver transplantation: A brief overview.World journal of virology · 2026Review
- EIF4H and YBX1 are essential host factors for hepatitis E virus replication and pathogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Integrated Transcriptomics Reveals a SHEV ORF3-Mediated circRNA Network That Disrupts Riboflavin Metabolism and Activates the ko05212 Pathway.Veterinary sciences · 2026Article
- Associations of ambient temperature and heat waves with risks of hepatitis E in Jiangsu, China (2010-2023): A time-stratified case-crossover study.Infectious Disease Modelling · 2026Article
- Shellfish as a Potential Source of Hepatitis E Virus: Epidemiological Evidence, Biological Plausibility, and Research Gaps.Viruses · 2026Review
126 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
At least 20 million hepatitis E virus (HEV) infections occur annually, with >3 million symptomatic cases and ∼60,000 fatalities. Hepatitis E is generally self-limiting, with a case fatality rate of 0.5-3% in young adults. However, it can cause up to 30% mortality in pregnant women in the third trimester and can become chronic in immunocompromised individuals, such as those receiving organ transplants or chemotherapy and individuals with HIV infection. HEV is transmitted primarily via the faecal-oral route and was previously thought to be a public health concern only in developing countries. It is now also being frequently reported in industrialized countries, where it is transmitted zoonotically or through organ transplantation or blood transfusions. Although a vaccine for HEV has been developed, it is only licensed in China. Additionally, no effective, non-teratogenic and specific treatments against HEV infections are currently available. Although progress has been made in characterizing HEV biology, the scarcity of adequate experimental platforms has hampered further research. In this Review, we focus on providing an update on the HEV life cycle. We will further discuss existing cell culture and animal models and highlight platforms that have proven to be useful and/or are emerging for studying other hepatotropic (viral) pathogens.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.