Evidence map›Paper›PMID 29162920›Full record

ArticleScientific reports2017

The corepressor NCOR1 regulates the survival of single-positive thymocytes.

Lena Müller, Daniela Hainberger, Valentina Stolz, Patricia Hamminger, Hammad Hassan, Teresa Preglej, Nicole Boucheron, Shinya Sakaguchi, G Jan Wiegers, Andreas Villunger and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 3 countries.

Lena MüllerDivision of Immunobiology, Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, 1090, Vienna, Austria.ORCID 0000-0002-6351-1786
Daniela HainbergerDivision of Immunobiology, Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, 1090, Vienna, Austria.
Valentina StolzDivision of Immunobiology, Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, 1090, Vienna, Austria.
Patricia HammingerDivision of Immunobiology, Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, 1090, Vienna, Austria.
Hammad HassanDivision of Immunobiology, Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, 1090, Vienna, Austria.
Teresa PreglejDivision of Immunobiology, Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, 1090, Vienna, Austria.
Nicole BoucheronDivision of Immunobiology, Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, 1090, Vienna, Austria.
Shinya SakaguchiDivision of Immunobiology, Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, 1090, Vienna, Austria.
G Jan WiegersInnsbruck Medical University, Biocenter, Division of Developmental Immunology, Innsbruck, Austria.
Andreas VillungerInnsbruck Medical University, Biocenter, Division of Developmental Immunology, Innsbruck, Austria.
Johan AuwerxEcole Polytechnique Fédérale de Lausanne, Laboratory of Integrative and Systems Physiology, Lausanne, Switzerland.
Wilfried EllmeierDivision of Immunobiology, Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, 1090, Vienna, Austria. wilfried.ellmeier@meduniwien.ac.at.
Medical University of Vienna · ATInnsbruck Medical University · ATAbdul Wali Khan University Mardan · PKÉcole Polytechnique Fédérale de Lausanne · CH

Funding

Austrian Science Fund FWF P 23641Austrian Science Fund FWF P 24265Austrian Science Fund FWF P 26193Austrian Science Fund FWF P 27747
6 · The paper itself

Abstract

Nuclear receptor corepressor 1 (NCOR1) is a transcriptional regulator bridging repressive chromatin modifying enzymes with transcription factors. NCOR1 regulates many biological processes, however its role in T cells is not known. Here we show that Cd4-Cre-mediated deletion of NCOR1 (NCOR1 cKO

Indexed as

AnimalsCell SurvivalGene DeletionInterleukin-7 Receptor alpha SubunitLymphocyte CountMice, KnockoutNuclear Receptor Co-Repressor 1Proto-Oncogene Proteins c-bcl-2Receptors, Antigen, T-Cell, alpha-betaThymocytesInterleukin-7 Receptor alpha SubunitNcor1 protein, mouseNuclear Receptor Co-Repressor 1Proto-Oncogene Proteins c-bcl-2Receptors, Antigen, T-Cell, alpha-beta

Identifiers

PMID29162920
PMCPMC5698297
OpenAlexW2768098204

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.