SynthesisScientific reports2017
Association of serum sodium and risk of all-cause mortality in patients with chronic kidney disease: A meta-analysis and sysematic review.
Synthesis in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- The role of point-of-care ultrasound in the evaluation and management of hyponatremia: a systematic review.Internal and emergency medicine · 2026Pooled it
- The Prognostic Value of Hyponatremia for Predicting Poor Outcome in Patients With COVID-19: A Systematic Review and Meta-Analysis.Frontiers in medicine · 2021Pooled it
- Prevalence and Prognostic Significance of Hyponatremia in Patients With Lung Cancer: Systematic Review and Meta-Analysis.Frontiers in medicine · 2021Pooled it
- Distinct osmoregulatory responses to sodium loading in patients with altered glycosaminoglycan structure: a randomized cross-over trial.Journal of translational medicine · 2021Trial
- Hyperbaric Oxygen Therapy - a Potential Therapy for Macro- and Trace Elements' Imbalance in Patients with Chronic Kidney Disease?Biological trace element research · 2026Article
- Review
- Comparison of AI-generated renal diets by different large language models: a guideline-based evaluation with expert input.BMC nephrology · 2026Article
- Baseline predictors of in-hospital mortality among patients with chronic kidney disease admitted to the emergency department.World journal of nephrology · 2025Article
- Prevalence of Hypernatremia Among Medically Hospitalized Patients and the Related Clinical Outcomes.Oman medical journal · 2025Article
- The Interplay Between Carotid Intima-Media Thickness and Selected Serum Biomarkers in Various Stages of Chronic Kidney Disease.Biomedicines · 2025Article
- Interaction between anemia and hyperuricemia in the risk of all-cause mortality in patients with chronic kidney disease.Frontiers in endocrinology · 2024Article
- Impact of serum sodium concentrations, and effect modifiers on mortality in the Irish Health System.BMC nephrology · 2023Article
- A step-by-step guide for the diagnosis and management of hyponatraemia in patients with stroke.Therapeutic advances in endocrinology and metabolism · 2023Review
- Hyponatremia in patients with arterial hypertension: pathophysiology and management.Archives of medical science : AMS · 2023Article
- Dysnatremias, Mortality, and Kidney Failure in CKD: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study.Kidney medicine · 2022Article
- Clinical predictors of hyponatremia in patients with heart failure according to severity of chronic kidney disease.Wiener klinische Wochenschrift · 2022Article
- Perturbed body fluid distribution and osmoregulation in response to high salt intake in patients with hereditary multiple exostoses.Molecular genetics and metabolism reports · 2021Article
- Hyponatremia: Is it related to the seasons?Journal of medical biochemistry · 2021Article
- Machine Learning Consensus Clustering of Hospitalized Patients with Admission Hyponatremia.Diseases (Basel, Switzerland) · 2021Article
- Hyponatremia as a prognostic factor in non-small cell lung cancer: a systematic review and meta-analysis.Translational lung cancer research · 2021Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Studies on the association of dysnatraemia with all-cause mortality risk in chronic kidney disease (CKD) patients have yielded inconsistent results. This meta-analysis aimed to evaluate the association of hyponatremia or hypernatremia with all-cause mortality risk in CKD patients. An electronic literature search was performed in Web of Science, Pubmed and Embase databases from inception to March 2017 for available observational studies evaluating the association of dysnatraemia with all-cause mortality risk in CKD patients. Pooled hazard risk (HR) with 95% confidence interval (CI) was calculated for hyponatremia or hypernatremia vs. normonatremia. Seven studies that enrolled 742,979 CKD patients were identified. Baseline hyponatremia (HR 1.34; 95% CI: 1.15-1.57), and not hypernatremia (HR 1.12; 95%: CI 0.93-1.34), was independently associated with increased risk of all-cause mortality, when compared than the normonatremia category. In time-dependent analyses, both time-averaged hyponatremia (HR 1.65; 95% CI: 1.27-2.15) and hypernatremia (HR 1.41; 95% CI: 1.20-1.65) had a higher independent risk of all-cause mortality. Furthermore, subgroup analyses by type of patients, study design, sample size and follow-up duration revealed similar results across most of these analyses. Baseline hyponatremia and time-dependent hyponatremia or hypernatremia were independently associated with increased all-cause mortality risk in CKD patients.
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