Evidence map›Paper›PMID 29162889›Full record

ArticleScientific reports2017

Identification of microRNAs as potential cellular monocytic biomarkers in the early phase of myocardial infarction: a pilot study.

Mariana S Parahuleva, Gerhild Euler, Amar Mardini, Behnoush Parviz, Bernhard Schieffer, Rainer Schulz, Muhammad Aslam

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Value of Serum miR-23a, miR-30d, and miR-146a Biomarkers in ST-Elevation Myocardial Infarction.Medical science monitor : international medical journal of experimental and clinical research · 2019
    Article
  9. Review
  10. Observational
  11. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Mariana S ParahulevaInternal Medicine/Cardiology and Angiology, University Hospital of Giessen and Marburg, Marburg, Germany. mariana.parahuleva@innere.med.uni-giessen.de.
Gerhild EulerInstitute of Physiology, Justus Liebig University, Giessen, Germany.
Amar MardiniInternal Medicine/Cardiology and Angiology, University Hospital of Giessen and Marburg, Marburg, Germany.
Behnoush ParvizInternal Medicine I/Cardiology and Angiology, University Hospital of Giessen and Marburg, Giessen, Germany.
Bernhard SchiefferInternal Medicine/Cardiology and Angiology, University Hospital of Giessen and Marburg, Marburg, Germany.
Rainer SchulzInstitute of Physiology, Justus Liebig University, Giessen, Germany.
Muhammad AslamInternal Medicine I/Cardiology and Angiology, University Hospital of Giessen and Marburg, Giessen, Germany.ORCID 0000-0002-8529-4217
Universitätsklinikum Gießen und Marburg · DEJustus-Liebig-Universität Gießen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MicroRNA has been increasingly suggested to be involved in vascular inflammation. The aim of this study was to assess the expression profile of miRs as possible novel cellular biomarkers in circulating monocytes in patients with ST-segment elevation myocardial infarction (STEMI). Microarray techniques and TaqMan polymerase chain reaction were used to analyse the global expression of 352 miRNAs in peripheral blood monocytes from healthy donors (n = 20) and patients (n = 24) with acute STEMI. The expression level of miR-143 in monocytes from STEMI patients compared to healthy controls was increased, whereas the expression of miR-1, -92a, -99a, and -223 was reduced significantly. During 3.5 ± 1.5 months of follow-up miR-1 and -223 were back to baseline, whereas miR-92a and -99a return to normal levels over 3 months, but remained lower than healthy controls. Furthermore, monocytic expression of miR-143 was positively correlated with hs-CRP (R

Indexed as

BiomarkersCase-Control StudiesDown-RegulationFemaleHumansInterferon-gammaLinear ModelsMaleMicroRNAsMiddle AgedMonocytesMyocardial InfarctionPilot ProjectsUp-RegulationBiomarkersInterferon-gammaMicroRNAs

Identifiers

PMID29162889
PMCPMC5698316
OpenAlexW2769469391

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.