ArticleScientific reports2017
An increased chloride level in hypochloremia is associated with decreased mortality in patients with severe sepsis or septic shock.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Mortality among adult patients with sepsis and septic shock in Korea: a systematic review and meta-analysis.Clinical and experimental emergency medicine · 2023Pooled it
- SGLT2 inhibitors preserve serum chloride in non-diabetic CKD: a propensity-matched and LASSO regression analysis.Renal failure · 2026Article
- A review on hypervirulent and multidrug-resistant Klebsiella pneumoniae: An emerging threat to human health.Naunyn-Schmiedeberg's archives of pharmacology · 2026Review
- Association of early chloride-bicarbonate joint phenotypes with in-hospital mortality among intensive care unit patients with sepsis: a dual-database study.Frontiers in medicine · 2026Article
- Longitudinal serum chloride trajectories and their correlation with all-cause mortality in critically Ill sepsis patients: a retrospective cohort analysis.BMC infectious diseases · 2025Article
- L-shape association between serum chloride and 365-day mortality in critically ill patients with sepsis based on the MIMIC-IV database.Scientific reports · 2025Article
- Association of serum chloride levels with all-cause mortality among patients in surgical intensive care units: a retrospective analysis of the MIMIC-IV database.BMC anesthesiology · 2025Article
- Hypochloremia: A Potential Indicator of Poor Outcomes in COVID-19.Medicina (Kaunas, Lithuania) · 2024Article
- Impact of hyperchloremia on inflammatory markers, serum creatinine, hemoglobin, and outcome in critically ill patients with COVID-19 infection.Journal of medicine and life · 2023Article
- Who would avoid severe adverse events from nasointestinal tube in small bowel obstruction? A matched case-control study.BMC gastroenterology · 2022Article
- Electrolyte and Acid-Base Disturbances in Emergency High-Risk Abdominal Surgery, a Retrospective Study.World journal of surgery · 2022Article
- Serum Chloride and Mortality in patients on continuous ambulatory peritoneal dialysis: A multi-center retrospective study.EClinicalMedicine · 2021Article
- Reduced intracellular chloride concentration impairs angiogenesis by inhibiting oxidative stress-mediated VEGFR2 activation.Acta pharmacologica Sinica · 2021Article
- Abnormal serum chloride is associated with increased mortality among unselected cardiac intensive care unit patients.PloS one · 2021Article
- Similarities between the effect of SARS-CoV-2 and HCV on the cellular level, and the possible role of ion channels in COVID19 progression: a review of potential targets for diagnosis and treatment.Channels (Austin, Tex.) · 2020Review
- Association between fluctuations in serum chloride levels and 30-day mortality among critically ill patients: a retrospective analysis.BMC anesthesiology · 2019Observational
- "I don't get no respect": the role of chloride in acute kidney injury.American journal of physiology. Renal physiology · 2019Review
- Increase in chloride from baseline is independently associated with mortality in critically ill children.Intensive care medicine · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Only a few observational studies investigated the association between hypochloremia and mortality in critically ill patients, and these studies included small number of septic patients. Also, no study has evaluated the effect of an increase in chloride (Cl
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.