ArticleNature communications2017
Intranasal infection and contact transmission of Zika virus in guinea pigs.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- Sexual Transmission of Arboviruses: A Systematic Review.Viruses · 2020Pooled it
- Sexual transmission of Zika virus and other flaviviruses: A living systematic review.PLoS medicine · 2018Pooled it
- The Laboratory Opossum (Viruses · 2024Article
- Emerging and reemerging infectious diseases: global trends and new strategies for their prevention and control.Signal transduction and targeted therapy · 2024Review
- Buccal Administration of a Zika Virus Vaccine Utilizing 3D-Printed Oral Dissolving Films in a Mouse Model.Vaccines · 2024Article
- Article
- Mice as an Animal Model for Japanese Encephalitis Virus Research: Mouse Susceptibility, Infection Route, and Viral Pathogenesis.Pathogens (Basel, Switzerland) · 2023Review
- Aerosolized Zika virus infection in Guinea pigs.Emerging microbes & infections · 2022Article
- Repeated Intravaginal Inoculation of Zika Virus Protects Cynomolgus Monkeys from Subcutaneous Superchallenge.International journal of molecular sciences · 2022Article
- Effective Infection with Dengue Virus in Experimental Neonate and Adult Mice through the Intranasal Route.Viruses · 2022Article
- Review
- Neurodevelopment in Children Exposed to ZikaFrontiers in genetics · 2022Review
- Characterization of subclinical ZIKV infection in immune-competent guinea pigs and mice.The Journal of general virology · 2021Article
- Three Immunocompetent Small Animal Models That Do Not Support Zika Virus Infection.Pathogens (Basel, Switzerland) · 2021Article
- Zika vaccine pre-clinical and clinical data review with perspectives on the future development.Human vaccines & immunotherapeutics · 2020Article
- Evidence That Zika Virus Is Transmitted by Breastfeeding to Newborn A129 (Frontiers in microbiology · 2020Article
- An optimized purified inactivated Zika vaccine provides sustained immunogenicity and protection in cynomolgus macaques.NPJ vaccines · 2020Article
- Maternal vaccination and protective immunity against Zika virus vertical transmission.Nature communications · 2019Article
- Article
- Zika virus enhances monocyte adhesion and transmigration favoring viral dissemination to neural cells.Nature communications · 2019Article
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Authors and funding
16 authors at 7 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Zika virus (ZIKV) is primarily transmitted to humans through mosquito bites or sexual contact. The excretion and persistence of contagious ZIKV in various body fluids have been well documented in ZIKV patients; however, the risk of direct contact exposure remains unclear. Here, we show that guinea pigs are susceptible to ZIKV infection via subcutaneous inoculation route; infected guinea pigs exhibit seroconversion and significant viral secretion in sera, saliva, and tears. Notably, ZIKV is efficiently transmitted from infected guinea pigs to naïve co-caged animals. In particular, intranasal inoculation of ZIKV is fully capable of establishing infection in guinea pigs, and viral antigens are detected in multiple tissues including brain and parotid glands. Cynomolgus macaques also efficiently acquire ZIKV infection via intranasal and intragastric inoculation routes. These collective results from animal models highlight the risk of exposure to ZIKV contaminants and raise the possibility of close contact transmission of ZIKV in humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.