Evidence map›Paper›PMID 29162813›Full record

ArticleNature communications2017

Chemogenomic analysis reveals key role for lysine acetylation in regulating Arc stability.

Jasmin Lalonde, Surya A Reis, Sudhir Sivakumaran, Carl S Holland, Hendrik Wesseling, John F Sauld, Begum Alural, Wen-Ning Zhao, Judith A Steen, Stephen J Haggarty

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Effect of pharmacological manipulations on Arc function.Current research in pharmacology and drug discovery · 2021
    Review
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 3 countries.

Jasmin LalondeChemical Neurobiology Laboratory, Massachusetts General Hospital, Center for Genomic Medicine, Departments of Neurology & Psychiatry, Harvard Medical School, 185 Cambridge Street, Boston, MA, 02114, USA. jlalon07@uoguelph.ca.ORCID http://orcid.org/0000-0002-6797-1894
Surya A ReisChemical Neurobiology Laboratory, Massachusetts General Hospital, Center for Genomic Medicine, Departments of Neurology & Psychiatry, Harvard Medical School, 185 Cambridge Street, Boston, MA, 02114, USA.
Sudhir SivakumaranDepartment of Anatomy and Neurobiology, Boston University School of Medicine, 72 East Concord, Boston, MA, 02118, USA.
Carl S HollandChemical Neurobiology Laboratory, Massachusetts General Hospital, Center for Genomic Medicine, Departments of Neurology & Psychiatry, Harvard Medical School, 185 Cambridge Street, Boston, MA, 02114, USA.
Hendrik WesselingBoston Children's Hospital, F.M. Kirby Center for Neurobiology, Harvard Medical School, 3 Blackfan Circle, Boston, MA, 02115, USA.
John F SauldBoston Children's Hospital, F.M. Kirby Center for Neurobiology, Harvard Medical School, 3 Blackfan Circle, Boston, MA, 02115, USA.
Begum AluralChemical Neurobiology Laboratory, Massachusetts General Hospital, Center for Genomic Medicine, Departments of Neurology & Psychiatry, Harvard Medical School, 185 Cambridge Street, Boston, MA, 02114, USA.
Wen-Ning ZhaoChemical Neurobiology Laboratory, Massachusetts General Hospital, Center for Genomic Medicine, Departments of Neurology & Psychiatry, Harvard Medical School, 185 Cambridge Street, Boston, MA, 02114, USA.
Judith A SteenBoston Children's Hospital, F.M. Kirby Center for Neurobiology, Harvard Medical School, 3 Blackfan Circle, Boston, MA, 02115, USA.
Stephen J HaggartyChemical Neurobiology Laboratory, Massachusetts General Hospital, Center for Genomic Medicine, Departments of Neurology & Psychiatry, Harvard Medical School, 185 Cambridge Street, Boston, MA, 02114, USA. shaggarty@mgh.harvard.edu.
Harvard University · USBoston Children's Hospital · USBoston University · US

Funding

Functional Genomics of Neuroplasticity in SchizophreniaR01MH095088 · NIMH · BROAD INSTITUTE, INC. · PI HAGGARTY, STEPHEN J · 2011 to 2014
$2.5M
NIMH NIH HHS R01 MH095088
6 · The paper itself

Abstract

The role of Arc in synaptic plasticity and memory consolidation has been investigated for many years with recent evidence that defects in the expression or activity of this immediate-early gene may also contribute to the pathophysiology of brain disorders including schizophrenia and fragile X syndrome. These results bring forward the concept that reversing Arc abnormalities could provide an avenue to improve cognitive or neurological impairments in different disease contexts, but how to achieve this therapeutic objective has remained elusive. Here, we present results from a chemogenomic screen that probed a mechanistically diverse library of small molecules for modulators of BDNF-induced Arc expression in primary cortical neurons. This effort identified compounds with a range of influences on Arc, including promoting its acetylation-a previously uncharacterized post-translational modification of this protein. Together, our data provide insights into the control of Arc that could be targeted to harness neuroplasticity for clinical applications.

Indexed as

AcetylationAmino Acid MotifsAnimalsBrain-Derived Neurotrophic FactorCytoskeletal ProteinsLysineMaleMiceMice, Inbred C57BLNerve Tissue ProteinsNeuronsProtein Stabilityactivity regulated cytoskeletal-associated proteinBrain-Derived Neurotrophic FactorCytoskeletal ProteinsLysineNerve Tissue Proteins

Identifiers

PMID29162813
PMCPMC5698418
OpenAlexW2769845883

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.