Evidence map›Paper›PMID 29162725›Full record

ArticleThe Journal of biological chemistry2018

Src homology 2 domains enhance tyrosine phosphorylation

Joshua A Jadwin, Timothy G Curran, Adam T Lafontaine, Forest M White, Bruce J Mayer

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. The fitness cost of spurious phosphorylation.bioRxiv : the preprint server for biology · 2023
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Adaptor Protein ShcD/Molecular cancer research : MCR · 2021
    Article
  12. Receptor Tyrosine Kinase Signaling and Targeting in Glioblastoma Multiforme.International journal of molecular sciences · 2021
    Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Joshua A JadwinFrom the Raymond and Beverly Sackler Laboratory of Molecular Medicine, Department of Genetics and Genome Sciences, and the Richard D. Berlin Center for Cell Analysis and Modeling, University of Connecticut School of Medicine, Farmington, Connecticut 06030 and.
Timothy G Curranthe Department of Biological Engineering and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139.
Adam T LafontaineFrom the Raymond and Beverly Sackler Laboratory of Molecular Medicine, Department of Genetics and Genome Sciences, and the Richard D. Berlin Center for Cell Analysis and Modeling, University of Connecticut School of Medicine, Farmington, Connecticut 06030 and.
Forest M Whitethe Department of Biological Engineering and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139.
Bruce J MayerFrom the Raymond and Beverly Sackler Laboratory of Molecular Medicine, Department of Genetics and Genome Sciences, and the Richard D. Berlin Center for Cell Analysis and Modeling, University of Connecticut School of Medicine, Farmington, Connecticut 06030 and bmayer@uchc.edu.
University of Connecticut · USMassachusetts Institute of Technology · US

Funding

TR&D4 Spatial Modeling: Modeling Framework for Cell MotilityP41GM103313 · NIGMS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI LOEW, LESLIE M · 2012 to 2018
$9.7M
Dynamics and Topology of Phosphotyrosine-SH2 Interaction NetworksU01CA154966 · NCI · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI MAYER, BRUCE J., WHITE, FOREST M · 2011 to 2015
$2.4M
A novel molecular diagnostic approach to classify lung cancers and predict responRC1CA146843 · NCI · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI HAURA, ERIC B., MAYER, BRUCE J. · 2009 to 2010
$983k
NCI NIH HHS RC1 CA146843NCI NIH HHS U01 CA154966NIGMS NIH HHS P41 GM103313
6 · The paper itself

Abstract

Phosphotyrosine (pTyr)-dependent signaling is critical for many cellular processes. It is highly dynamic, as signal output depends not only on phosphorylation and dephosphorylation rates but also on the rates of binding and dissociation of effectors containing phosphotyrosine-dependent binding modules such as Src homology 2 (SH2) and phosphotyrosine-binding (PTB) domains. Previous

Indexed as

Binding SitesErbB ReceptorsGRB2 Adaptor ProteinPhosphorylationPhosphotyrosineProtein BindingSignal TransductionErbB ReceptorsGRB2 Adaptor ProteinPhosphotyrosinecrkepidermal growth factor receptor (EGFR)growth factor receptor-bound protein 2 (GRB2)phosphorylationphosphotyrosineSrc homology 2 domain (SH2 domain)

Identifiers

PMID29162725
PMCPMC5767867
OpenAlexW2768376248

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.