Evidence map›Paper›PMID 29162715›Full record

ArticlemBio2017

Bacteriophage Transcytosis Provides a Mechanism To Cross Epithelial Cell Layers.

Sophie Nguyen, Kristi Baker, Benjamin S Padman, Ruzeen Patwa, Rhys A Dunstan, Thomas A Weston, Kyle Schlosser, Barbara Bailey, Trevor Lithgow, Michael Lazarou and 4 more

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in mBio, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 221 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
221citing papers in PubMed, 1 pooled it
26.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

221 citing papers in PubMed, 1 synthesis or guideline pooled it, 353 citations in OpenAlex.

  1. Pooled it
  2. Engineering the probioticSynthetic and systems biotechnology · 2026
    Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Comprehensive analysis of the gastric metatranscriptome reveals specific viral signatures associated with gastric cancer.International microbiology : the official journal of the Spanish Society for Microbiology · 2026
    Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Immune Responses to Phage Therapy in Humans: A Review.The Journal of infectious diseases · 2026
    Review
  16. Review
  17. Review
  18. Review
  19. Review
  20. Article

161 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Sophie NguyenDepartment of Biology, San Diego State University, San Diego, California, USA.
Kristi BakerDivision of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Benjamin S PadmanDepartment of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
Ruzeen PatwaSchool of the Biological Sciences, Monash University, Clayton, Victoria, Australia.
Rhys A DunstanInfection and Immunity Program, Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, Victoria, Australia.
Thomas A WestonDepartment of Biology, San Diego State University, San Diego, California, USA.
Kyle SchlosserDepartment of Biology, San Diego State University, San Diego, California, USA.
Barbara BaileyDepartment of Mathematics and Statistics, San Diego State University, San Diego, California, USA.
Trevor LithgowInfection and Immunity Program, Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, Victoria, Australia.
Michael LazarouDepartment of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
Antoni LuqueDepartment of Mathematics and Statistics, San Diego State University, San Diego, California, USA.
Forest RohwerDepartment of Biology, San Diego State University, San Diego, California, USA.
Richard S BlumbergDivision of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Jeremy J BarrDepartment of Biology, San Diego State University, San Diego, California, USA jeremybarr85@gmail.com.
San Diego State University · USMonash University · AUHarvard University · USAustralian Regenerative Medicine Institute · AU

Funding

INTESTINAL TRANSCYTOSIS OF IGG IN ADULT LIFER01DK053056 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI BLUMBERG, RICHARD S · 1997 to 2021
$10.6M
Intestinal Immune Regulation by IgG and FcRnR56DK053056 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI BLUMBERG, RICHARD S · 2017 to 2017
$100k
NIDDK NIH HHS R01 DK053056NIDDK NIH HHS R56 DK053056
6 · The paper itself

Abstract

Bacterial viruses are among the most numerous biological entities within the human body. These viruses are found within regions of the body that have conventionally been considered sterile, including the blood, lymph, and organs. However, the primary mechanism that bacterial viruses use to bypass epithelial cell layers and access the body remains unknown. Here, we used

Indexed as

TranscytosisBacteriophagesCell LineCytosolEndocytosisEpithelial CellsGastrointestinal TractHumansKidneyLiverLungMicroscopySymbiosisbacteriophagesendocytosisphage-eukaryotic interactionsymbiosistranscytosis

Identifiers

PMID29162715
PMCPMC5698557
OpenAlexW2769152635

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.