Evidence map›Paper›PMID 29162712›Full record

ArticlemBio2017

Persistence of an Oncogenic Papillomavirus Genome Requires

Koenraad Van Doorslaer, Dan Chen, Sandra Chapman, Jameela Khan, Alison A McBride

Open access · goldAbstract read
In one paragraph

Article in mBio, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Koenraad Van DoorslaerLaboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Dan ChenLaboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Sandra ChapmanLaboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Jameela KhanLaboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Alison A McBrideLaboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA amcbride@nih.gov.ORCID 0000-0001-5607-5157
National Institutes of Health · US

Funding

Replication mechanisms of human papillomaviruses (HPV)ZIAAI000713 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI MCBRIDE, ALISON · 2009 to 2025
$12.4M
HPV Elements Required for Alpha HPV Genome Replication and PartitioningZIAAI001073 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI MCBRIDE, ALISON · 2009 to 2017
$2.7M
Intramural NIH HHS ZIA AI001073
6 · The paper itself

Abstract

Human papillomavirus (HPV) genomes are replicated and maintained as extrachromosomal plasmids during persistent infection. The viral E2 proteins are thought to promote stable maintenance replication by tethering the viral DNA to host chromatin. However, this has been very difficult to prove genetically, as the E2 protein is involved in transcriptional regulation and initiation of replication, as well as its assumed role in genome maintenance. This makes mutational analysis of viral

Indexed as

Genome, ViralBinding SitesDNA-Binding ProteinsDNA ReplicationDNA, ViralGene Expression Regulation, ViralGenetic Complementation TestHumansKeratinocytesMutationOncogene Proteins, ViralPapillomaviridaeRegulatory Sequences, Nucleic AcidTranscription FactorsViral ProteinsVirus ReplicationDNA-Binding ProteinsDNA, Viraloncogene protein E2, Human papillomavirus type 1Oncogene Proteins, ViralTranscription FactorsViral ProteinsDNA replicationHPVkeratinocytepapillomaviruspartitioningpersistent replicationstable replicationviral replication

Identifiers

PMID29162712
PMCPMC5698554
OpenAlexW2769933492

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.