Evidence map›Paper›PMID 29162702›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2018

Structural basis for the antiarrhythmic blockade of a potassium channel with a small molecule.

Yoshio Takemoto, Diana P Slough, Gretchen Meinke, Christopher Katnik, Zachary A Graziano, Bojjibabu Chidipi, Michelle Reiser, Mohammed M Alhadidy, Rafael Ramirez, Oscar Salvador-Montañés and 9 more

Open access · bronzeAbstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. Increased Density of Endogenous Adenosine AInternational journal of molecular sciences · 2023
    Article
  3. Mechanism of PKCε regulation of cardiac GIRK channel gating.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  4. Review
  5. Bioengineered peptibodies as blockers of ion channels.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  6. IiScience · 2022
    Article
  7. Review
  8. Review
  9. Cardiac effects and toxicity of chloroquine: a short update.International journal of antimicrobial agents · 2020
    Review
  10. Article
  11. Article
  12. Article
  13. MulticellularFrontiers in cardiovascular medicine · 2020
    Review
  14. Article
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 6 institutions in 4 countries.

Yoshio TakemotoDepartment of Cardiovascular Research, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan.
Diana P SloughDepartment of Chemistry, Tufts University, Medford, Massachusetts, USA.
Gretchen MeinkeDepartment of Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, Boston, Massachusetts, USA.
Christopher KatnikMolecular Pharmacology and Physiology Department, University of South Florida, Tampa, Florida, USA.
Zachary A GrazianoDepartment of Chemistry, Tufts University, Medford, Massachusetts, USA.
Bojjibabu ChidipiMolecular Pharmacology and Physiology Department, University of South Florida, Tampa, Florida, USA.
Michelle ReiserMolecular Pharmacology and Physiology Department, University of South Florida, Tampa, Florida, USA.
Mohammed M AlhadidyMolecular Pharmacology and Physiology Department, University of South Florida, Tampa, Florida, USA.
Rafael RamirezCenter for Arrhythmia Research, University of Michigan, Ann Arbor, Michigan, USA.
Oscar Salvador-MontañésCenter for Arrhythmia Research, University of Michigan, Ann Arbor, Michigan, USA.
Steven EnnisCenter for Arrhythmia Research, University of Michigan, Ann Arbor, Michigan, USA.
Guadalupe Guerrero-SernaCenter for Arrhythmia Research, University of Michigan, Ann Arbor, Michigan, USA.
Marian HaburcakDepartment of Biology, Brandeis University, Waltham, Massachusetts, USA.
Carl DiehlSaromics Biostructures, Copenhagen, Denmark; and.
Javier CuevasMolecular Pharmacology and Physiology Department, University of South Florida, Tampa, Florida, USA.
Jose JalifeCenter for Arrhythmia Research, University of Michigan, Ann Arbor, Michigan, USA.
Andrew BohmDepartment of Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, Boston, Massachusetts, USA.
Yu-Shan LinDepartment of Chemistry, Tufts University, Medford, Massachusetts, USA.
Sami F NoujaimMolecular Pharmacology and Physiology Department, University of South Florida, Tampa, Florida, USA.
University of South Florida · USTufts University · USUniversity of Michigan–Ann Arbor · USBrandeis University · USCentro de Investigación Biomédica en Red · ESSARomics Biostructures (Sweden) · SE

Funding

Molecular Mechanisms for Atrial Fibrillation in AgingR01HL129136 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI NOUJAIM, SAMI FOUAD · 2015 to 2019
$2.0M
Intermolecular Interactions of NaV1.5 and Kir2.1 In Ion Channel DiseasesR01HL122352 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BERENFELD, OMER · 2015 to 2018
$1.9M
Bioengineered peptibodies as antiarrhythmic therapy in atrial fibrillationR21HL138064 · NHLBI · UNIVERSITY OF SOUTH FLORIDA · PI NOUJAIM, SAMI FOUAD · 2017 to 2018
$411k
NHLBI NIH HHS R01 HL122352NHLBI NIH HHS R01 HL129136NHLBI NIH HHS R21 HL138064
6 · The paper itself

Abstract

The acetylcholine-activated inward rectifier potassium current ( I

Indexed as

Molecular Docking SimulationAmino Acid SubstitutionAnimalsAnti-Arrhythmia AgentsBinding SitesChloroquineG Protein-Coupled Inwardly-Rectifying Potassium ChannelsHeart RateHEK293 CellsHumansMalePotassium Channel BlockersProtein BindingSheepAnti-Arrhythmia AgentsChloroquineG Protein-Coupled Inwardly-Rectifying Potassium ChannelsPotassium Channel Blockersatrial fibrillationIKAChpotassium inward rectifier

Identifiers

PMID29162702
PMCPMC5893172
OpenAlexW2770260091

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.