Evidence map›Paper›PMID 29162699›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

Edward R Kastenhuber, Gadi Lalazar, Shauna L Houlihan, Darjus F Tschaharganeh, Timour Baslan, Chi-Chao Chen, David Requena, Sha Tian, Benedikt Bosbach, John E Wilkinson and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 117 papers.

0numbers the graph read from it
0cells of the map it votes in
117citing papers in PubMed
5.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

117 citing papers in PubMed, 160 citations in OpenAlex.

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  5. 7-azaindole as privileged scaffold: Advances in drug design and structural modification.Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2026
    Review
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57 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Edward R KastenhuberDepartment of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
Gadi LalazarLaboratory of Cellular Biophysics, The Rockefeller University, New York, NY 10065.
Shauna L HoulihanDepartment of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
Darjus F TschaharganehHelmholtz University Group "Cell Plasticity and Epigenetic Remodeling," German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Timour BaslanDepartment of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
Chi-Chao ChenDepartment of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
David RequenaLaboratory of Cellular Biophysics, The Rockefeller University, New York, NY 10065.
Sha TianDepartment of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY 10065.
Benedikt BosbachOncology Target Discovery Program, Pfizer Inc., Pearl River, NY 10965.
John E WilkinsonDepartment of Pathology, University of Michigan School of Medicine, Ann Arbor, MI 48109.
Sanford M SimonLaboratory of Cellular Biophysics, The Rockefeller University, New York, NY 10065.
Scott W LoweDepartment of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY 10065; lowes@mskcc.org.
Memorial Sloan Kettering Cancer Center · USRockefeller University · USGerman Cancer Research Center · DETarget (United States) · USUniversity of Michigan–Ann Arbor · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
VIRAL TRANSACTIVATIONP01CA013106 · NCI · COLD SPRING HARBOR LABORATORY · PI DAVID L SPECTOR · 1985 to 2026
$116.8M
Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational SuccessUL1TR001866 · NCATS · ROCKEFELLER UNIVERSITY · PI COLLER, BARRY, KRUEGER, JAMES G · 2016 to 2025
$40.6M
MSKCC Pilot Center for Precision Disease ModelingU54OD020355 · OD · SLOAN-KETTERING INST CAN RESEARCH · PI LOWE, SCOTT W., SOLIT, DAVID B. · 2015 to 2019
$9.9M
Cellular Pathogenesis of Fibrolamellar Hepatocellular CarcinomaR56CA207929 · NCI · ROCKEFELLER UNIVERSITY · PI SIMON, SANFORD M · 2016 to 2017
$593k
Intratumoral Heterogeneity and Tumor Evolution in LymphomaF31CA192835 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI KASTENHUBER, EDWARD R · 2015 to 2018
$157k
Howard Hughes Medical InstituteNCATS NIH HHS UL1 TR001866NCI NIH HHS F31 CA192835NCI NIH HHS P01 CA013106NCI NIH HHS P30 CA008748NCI NIH HHS R56 CA207929NIH HHS U54 OD020355
6 · The paper itself

Abstract

A segmental deletion resulting in

Indexed as

AdultAnimalsBase Sequencebeta CateninCarcinogenesisCarcinoma, HepatocellularChromosomes, Human, Pair 19Clustered Regularly Interspaced Short Palindromic RepeatsCohort StudiesCyclic AMP-Dependent Protein Kinase Catalytic SubunitsFemaleGene Expression Regulation, NeoplasticHSP40 Heat-Shock ProteinsHumansLiverLiver Neoplasms3,5-diethoxycarbonyl-1,4-dihydrocollidinebeta CateninCTNNB1 protein, humanCTNNB1 protein, mouseCyclic AMP-Dependent Protein Kinase Catalytic SubunitsDNAJB1 protein, humanDnajb1 protein, mouseHSP40 Heat-Shock ProteinsOncogene Proteins, FusionPRKACA protein, humanPrkaca protein, mousePyridinesCRISPRfibrolamellar hepatocellular carcinomamouse cancer modelsprotein kinase Aβ-catenin

Identifiers

PMID29162699
PMCPMC5740683
OpenAlexW2953258979

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.