ArticleThe Journal of cell biology2018
MRCKα is activated by caspase cleavage to assemble an apical actin ring for epithelial cell extrusion.
Article in The Journal of cell biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 31 citations in OpenAlex.
- Tissue turnover and rejuvenation through mechanics.Frontiers in cell and developmental biology · 2026Review
- The desmosome-intermediate filament system facilitates mechanotransduction at adherens junctions for epithelial homeostasis.Current biology : CB · 2024Article
- MRCK activates mouse oocyte myosin II for spindle rotation and male pronucleus centration.The Journal of cell biology · 2023Article
- Cell adhesion molecule BVES functions as a suppressor of tumor cells extrusion in hepatocellular carcinoma metastasis.Cell communication and signaling : CCS · 2022Article
- Optogenetic activators of apoptosis, necroptosis, and pyroptosis.The Journal of cell biology · 2022Article
- Regulating life after death: how mechanical communication mediates the epithelial response to apoptosis.The European physical journal. E, Soft matter · 2022Review
- Early mechanical selection of cell extrusion and extrusion signaling in cancer.Current opinion in cell biology · 2021Review
- Orchestration of Force Generation and Nuclear Collapse in Apoptotic Cells.International journal of molecular sciences · 2021Review
- MRCK: a master regulator of tissue remodeling or another 'ROCK' in the epithelial block?Tissue barriers · 2021Review
- Pulsatile contractions promote apoptotic cell extrusion in epithelial tissues.Current biology : CB · 2021Article
- Article
- Adhesion-mediated heterogeneous actin organization governs apoptotic cell extrusion.Nature communications · 2021Article
- Src kinases relax adherens junctions between the neighbors of apoptotic cells to permit apical extrusion.Molecular biology of the cell · 2020Article
- Death for life: a path from apoptotic signaling to tissue-scale effects of apoptotic epithelial extrusion.Cellular and molecular life sciences : CMLS · 2019Review
- Cell injury triggers actin polymerization to initiate epithelial restitution.Journal of cell science · 2018Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Extrusion of apoptotic cells from epithelial tissues requires orchestrated morphological rearrangements of the apoptotic cell and its neighbors. However, the connections between the apoptotic cascade and events leading to extrusion are not fully understood. Here, we characterize an apoptotic extrusion apical actin ring (EAAR) that is assembled within the apoptotic cell and drives epithelial extrusion. Caspase-mediated cleavage of myotonic dystrophy kinase-related CDC42-binding kinase-α (MRCKα) triggers a signaling pathway that leads to the assembly of EAAR that pulls actin bundles, resulting in the compaction and removal of the cell body. We provide a detailed portrait of the EAAR including F-actin flow, the contribution of myosin contraction, and actin polymerization at bundles' terminals when the product of MRCKα cleavage is expressed. These results add to our understanding of the mechanisms controlling the process of epithelial extrusion by establishing a causal relationship between the triggering events of apoptosis, the activation of MRCKα, and its subsequent effects on the dynamics of actomyosin cytoskeleton rearrangement.
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