Evidence map›Paper›PMID 29162582›Full record

ReviewDiabetes care2017

Standardizing Clinically Meaningful Outcome Measures Beyond HbA

Gina Agiostratidou, Henry Anhalt, Dana Ball, Lawrence Blonde, Evgenia Gourgari, Karen N Harriman, Aaron J Kowalski, Paul Madden, Alicia H McAuliffe-Fogarty, Molly McElwee-Malloy and 5 more

Open access · bronzeAbstract readReviewConsensus Statement
In one paragraph

Review in Diabetes care, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 192 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
192citing papers in PubMed, 13 pooled it
27.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

192 citing papers in PubMed, 13 syntheses or guidelines pooled it, 393 citations in OpenAlex.

  1. Pooled it
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  3. Real-World Evidence of Automated Insulin Delivery System Use.Diabetes technology & therapeutics · 2024
    Pooled it
  4. Guideline
  5. American Association of Clinical Endocrinology Clinical Practice Guideline: Developing a Diabetes Mellitus Comprehensive Care Plan-2022 Update.Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 2022
    Guideline
  6. Pooled it
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  10. Guideline
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  13. Pooled it
  14. Trial
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132 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 7 institutions in 1 country.

Gina AgiostratidouThe Leona M. and Harry B. Helmsley Charitable Trust, New York, NY.
Henry AnhaltT1D Exchange, Boston, MA.
Dana BallT1D Exchange, Boston, MA.
Lawrence BlondeAmerican Association of Clinical Endocrinologists, Jacksonville, FL.
Evgenia GourgariEndocrine Society, Washington, DC.
Karen N HarrimanAmerican Association of Diabetes Educators, Chicago, IL.
Aaron J KowalskiJDRF International, New York, NY akowalski@jdrf.org.
Paul MaddenAmerican Diabetes Association, Arlington, VA.
Alicia H McAuliffe-FogartyAmerican Diabetes Association, Arlington, VA.
Molly McElwee-MalloyAmerican Association of Diabetes Educators, Chicago, IL.
Anne PetersEndocrine Society, Washington, DC.
Sripriya RamanAmerican Association of Clinical Endocrinologists, Jacksonville, FL.
Kent ReifschneiderPediatric Endocrine Society, McLean, VA.
Karen RubinPediatric Endocrine Society, McLean, VA.
Stuart A WeinzimerPediatric Endocrine Society, McLean, VA.
Endocrine Society · USAmerican Association of Clinical Endocrinologists · USAmerican Association of Diabetes Educators · USAmerican Diabetes Association · UST1D Exchange · USBreakthrough T1D · USLeona M. and Harry B. Helmsley Charitable Trust · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Institutional Career Development CoreKL2TR001432 · NCATS · GEORGETOWN UNIVERSITY · PI UMANS, JASON G · 2015 to 2024
$7.5M
NCATS NIH HHS KL2 TR001432NCATS NIH HHS UL1 TR001863
6 · The paper itself

Abstract

objectiveTo identify and define clinically meaningful type 1 diabetes outcomes beyond hemoglobin A RESEARCH AND

methodsA Steering Committee-comprising representatives from the American Association of Clinical Endocrinologists, the American Association of Diabetes Educators, the American Diabetes Association, the Endocrine Society, JDRF International, The Leona M. and Harry B. Helmsley Charitable Trust, the Pediatric Endocrine Society, and the T1D Exchange-was the decision-making body for the Type 1 Diabetes Outcomes Program. Their work was informed by input from researchers, industry, and people with diabetes through Advisory Committees representing each stakeholder group. Stakeholder surveys were used to identify priority outcomes. The outcomes prioritized in the surveys were hypoglycemia, hyperglycemia, time in range, DKA, and PROs. To develop consensus on the definitions of these outcomes, the Steering Committee relied on published evidence, their clinical expertise, and feedback from the Advisory Committees.

resultsThe Steering Committee developed definitions for hypoglycemia, hyperglycemia, time in range, and DKA in type 1 diabetes. The definitions reflect their assessment of the outcome's short- and long-term clinical impact on people with type 1 diabetes. Knowledge gaps to be addressed by future research were identified. The Steering Committee discussed PROs and concluded that further type 1 diabetes-specific development is needed.

conclusionsThe Steering Committee recommends use of the defined clinically meaningful outcomes beyond HbA

Indexed as

Diabetes Mellitus, Type 1Diabetes Mellitus, Type 2Diabetic KetoacidosisEndocrinologistsEndocrinologyGlycated HemoglobinHumansHyperglycemiaHypoglycemiaOutcome Assessment, Health CareSocieties, MedicalUnited StatesGlycated Hemoglobin

Identifiers

PMID29162582
PMCPMC5864122
OpenAlexW2769674107

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.