ArticleBMJ open2017
Cohort profile: the Mayo Clinic Cohort Study of Oophorectomy and Aging-2 (MOA-2) in Olmsted County, Minnesota (USA).
Article in BMJ open, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 43 citations in OpenAlex.
- Ovarian Function Suppression in Premenopausal Hormone Receptor-Positive Early Breast Cancer: A Comprehensive Review.Journal of breast cancer · 2026Review
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- Habitual physical activity and sedentary behavior among women with and without premenopausal bilateral oophorectomy: an exploratory study.Menopause (New York, N.Y.) · 2025Article
- Article
- Article
- Adverse childhood experiences increase the long-term accumulation of morbidity in women.Communications medicine · 2025Article
- Premenopausal bilateral oophorectomy and Alzheimer's disease imaging biomarkers later in life.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Are adverse childhood experiences associated with trajectories of healthy aging? Evidence from China.SSM - population health · 2023Article
- Smoking, early menopause and multiple sclerosis disease course.Climacteric : the journal of the International Menopause Society · 2023Article
- Frequency and type of premature or early menopause in a geographically defined American population.Maturitas · 2023Article
- A population-based cohort study on the risk of obstructive lung disease after bilateral oophorectomy.NPJ primary care respiratory medicine · 2022Article
- Trajectories of metabolic parameters after bilateral oophorectomy in premenopausal women.Maturitas · 2022Article
- Association of Premenopausal Bilateral Oophorectomy With Parkinsonism and Parkinson Disease.JAMA network open · 2022Article
- Risk of de novo cancer after premenopausal bilateral oophorectomy.American journal of obstetrics and gynecology · 2022Article
- Identifying Information Gaps in Electronic Health Records by Using Natural Language Processing: Gynecologic Surgery History Identification.Journal of medical Internet research · 2022Article
- Premature or early bilateral oophorectomy: a 2021 update.Climacteric : the journal of the International Menopause Society · 2021Article
- Prognostic factors for ovarian metastases in colorectal cancer patients.World journal of surgical oncology · 2021Article
- Association of Premenopausal Bilateral Oophorectomy With Restless Legs Syndrome.JAMA network open · 2021Article
- Hysterectomy and Oophorectomy in Reproductive Age: A Cross-Sectional Study from a Tertiary Care Hospital.Cureus · 2020Article
- Catamenial rectal bleeding due to invasive endometriosis: a case report.Journal of medical case reports · 2020Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
purposeThis cohort study was established to investigate the effects of unilateral and bilateral oophorectomy on the ageing processes in women.
participantsWe used the records-linkage system of the Rochester Epidemiology Project (REP, http://www.rochesterproject.org) to identify 570 women who underwent unilateral oophorectomy and 1653 women who underwent bilateral oophorectomy in Olmsted County, Minnesota from 1988 through 2007 (20 years). Each woman was matched by age (±1 year) to a population-based referent woman who had not undergone any oophorectomy (570 referent women) or bilateral oophorectomy (1653 referent women). These four cohorts are being followed to assess morbidity and mortality and to study imaging and biological markers related to ageing. FINDINGS TO DATE: An extensive medical record abstraction using the REP has been completed for each woman to obtain demographic, reproductive and adult life characteristics and extensive clinical information about the surgical procedure and subsequent oestrogen replacement therapy (or other sex steroid therapy). The cohorts have been used to date to study the accumulation of multiple chronic conditions following bilateral oophorectomy in women with or without chronic conditions at the time of the oophorectomy (or index date). From the cohorts, we have also derived a sample of 128 pairs of women for a case-control study linking adverse childhood or adult experiences to the risk of bilateral oophorectomy. FUTURE PLANS: We hypothesise that the abrupt hormonal changes caused by bilateral oophorectomy in younger women have a major effect on the ageing processes across the full body. Therefore, we plan to investigate the risk of a wide range of chronic conditions following bilateral oophorectomy. Specific studies are underway for kidney diseases, psychiatric diseases and neurological diseases. In addition, we plan to invite a subsample of women from the bilateral oophorectomy cohort to participate in an in-person study involving brain imaging and the collection of biomarkers.
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